Allelic imbalance at 13q14.2∼q14.3 in localized prostate cancer is associated with early biochemical relapse
Allelic imbalance at 13q14.2∼q14.3 in localized prostate cancer is associated with early biochemical relapse
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DOI：
10.1016/j.cancergencyto.2007.08.017
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发表时间：
2007-12-01
影响因子：
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通讯作者：
Feneley, Mark R.
中科院分区：
文献类型：
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作者：
Brookman-Amissah, Nicola;Nariculam, Joseph;Feneley, Mark R.
等位基因不平衡(AI)是散发性前列腺癌最常见的遗传改变，尤其是染色体8p、10q和13q。这些部位的人工智能可能会使调节正常细胞生长的肿瘤抑制基因失活。为了确定AI与疾病进展的关系，我们分析了Gleason分级、术前前列腺特异性抗原水平和病理分期匹配的前列腺癌8p、10q和13q14上的基因座，并根据3年后的复发情况将它们配对。在没有复发的患者中，66%的患者发现了AI，而在复发的患者中，有73%的患者发现了AI。8p21.3和10q23.2位点AI在两组间差异无统计学意义，而D13S165位13q14.2(P=0.006)和D13S273位13q14.3位(P=0.03)AI频率在复发组和未复发组之间差异有统计学意义。复发组两个基因座AI的发生率也显著高于未复发组(P=0.03)。在三个复吸者中，AI发生在13q14.2至13q14.3之间的所有三个基因座上，没有未复吸者在所有三个基因座上表现出AI。这些发现表明，13q14.2-q14.3的AI在局限性前列腺癌的进展过程中是一个重要事件，并提示了microRNAs可能的作用。(C)2007 Elsevier Inc.保留所有权利。
Allelic imbalance (AI), particularly at chromosomes 8p, 10q, and 13q, is the most frequently observed genetic change in sporadic prostate cancer. AI at these sites may inactivate tumor suppressor genes that regulate normal cell growth. To establish the relationship between AI and progression, we analyzed loci on 8p, 10q, and 13q14 in archival prostate tumors matched for Gleason grade, pre-operative prostate-specific antigen levels, and pathologic stage, and they were paired on the basis of relapse status after 3 years. AI was identified in 66% of patients without relapse and in 73% with relapse. There was no statistically significant difference for AI at 8p21.3 and 10q23.2 between the two groups of patients, but significant differences between relapsers and nonrelapsers in the frequency of AI at D13S165 at 13q14.2 (P=0.006) and D13S273 at 13q14.3 (P=0.03). There was also a significantly higher incidence of AI at both loci in the relapsers compared to the nonrelapsers (P=0.03). In three relapsers, AI occurred at all three loci between 13q14.2 and 13q14.3, with no nonrelapsers demonstrating AI at all three loci. These findings show that AI at 13q14.2-q14.3 is an important event in the progression of localized prostate cancer, and suggest a possible role for microRNAs. (c) 2007 Elsevier Inc. All rights reserved.