Comparative approaches to the study of physiology: Drosophila as a physiological tool.
Comparative approaches to the study of physiology: Drosophila as a physiological tool.
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DOI：
10.1152/ajpregu.00084.2012
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发表时间：
2013-02
期刊：
影响因子：
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通讯作者：
W. Neckameyer;K. J. Argue
中科院分区：
文献类型：
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作者：
W. Neckameyer;K. J. Argue
许多研究已经详细说明了模型系统，黑腹果蝇和哺乳动物模型之间的发育信号通路的广泛保守性，但研究人员也从该系统中可用的独特且高度易处理的遗传工具中获益，以解决生理学中的关键问题。在这篇综述中，我们描述了果蝇研究人员对模式形成的数学动力学、心脏病理学、疼痛回路被整合以引起感觉反应的方式以及基因表达可以调节不同行为并揭示人类认知障碍的方式所做的贡献。果蝇的广泛而多样的贡献强调了其对人类疾病建模的翻译相关性。
Numerous studies have detailed the extensive conservation of developmental signaling pathways between the model system, Drosophila melanogaster, and mammalian models, but researchers have also profited from the unique and highly tractable genetic tools available in this system to address critical questions in physiology. In this review, we have described contributions that Drosophila researchers have made to mathematical dynamics of pattern formation, cardiac pathologies, the way in which pain circuits are integrated to elicit responses from sensation, as well as the ways in which gene expression can modulate diverse behaviors and shed light on human cognitive disorders. The broad and diverse array of contributions from Drosophila underscore its translational relevance to modeling human disease.