A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foraging
A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foraging
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DOI：
10.1016/0166-4328(96)00031-9
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发表时间：
1996-10-01
影响因子：
2.7
通讯作者：
Phillips, AG
中科院分区：
文献类型：
--
作者：
Floresco, SB;Seamans, JK;Phillips, AG
通过向伏隔核(N.Acc.)注入低剂量的DA拮抗剂氟哌啶醇来评估中枢多巴胺(DA)在放射臂迷宫觅食中的作用。将氟哌啶醇(0、12 5、2 5 0或5 0 0 ng/0.5亩L)注入N.在随机觅食任务中，训练有素的大鼠的重新进入手臂的次数(错误)随剂量增加，在8臂迷宫上的4只手臂被随机放置诱饵。然而，在另一组动物中，类似的输液在延迟的空间赢移任务的测试阶段之前进行时不会产生损害，这要求动物在训练阶段获取信息，并在30分钟后的测试阶段使用这些信息。这些结果提示，中缝大核的多巴胺神经传递。当空间环境中奖励的位置不明确时，对觅食行为至关重要，但当动物之前有关于奖励刺激位置的信息时，对于有效的觅食行为来说不是必需的。讨论了边缘谷氨酸和中央伏隔区DA传递之间的潜在生理相互作用。
The role of mesoaccumbens dopamine (DA) in radial-arm maze foraging is assessed by infusing low doses of the DA antagonist haloperidol into the nucleus accumbens (N.Acc.). Infusions of haloperidol (0, 125, 250 or 500 ng/0.5 mu l) into the N.Acc. of well-trained rats dose-dependently increase the number of re-entries to arms (errors) during the random foraging task, in which 4 arms on an 8-arm maze are baited randomly. However, in a separate group of animals, similar infusions produce no impairment when delivered prior to the test phase of the delayed spatial win-shift task, which require the animal to acquire information during a training phase, and to use that information 30 min later, during a test phase. These results suggest that DA neurotransmission in the N.Acc. is crucial for foraging behavior when there is ambiguity about the location of reward in a spatial environment, but is not needed for efficient foraging behavior when an animal has previous information as to the location of rewarding stimuli. The results are discussed with respect to of the underlying physiological interactions between limbic glutamate and mesoaccumbens DA transmission in the N.Acc.