TRANSIENT EXPRESSION OF 5-HT1A RECEPTOR-BINDING SITES IN SOME AREAS OF THE RAT CNS DURING POSTNATAL-DEVELOPMENT
TRANSIENT EXPRESSION OF 5-HT1A RECEPTOR-BINDING SITES IN SOME AREAS OF THE RAT CNS DURING POSTNATAL-DEVELOPMENT
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DOI：
10.1016/0736-5748(87)90027-x
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发表时间：
1987-01-01
影响因子：
1.8
通讯作者：
HAMON, M
中科院分区：
文献类型：
--
作者：
DAVAL, G;VERGE, D;HAMON, M
使用定量放射自显影和以 3H-8-OH-DPAT 作为选择性配体的结合测定，在出生后早期检查大鼠 CNS 中 5-HT1A 受体结合位点的发育进化。在海马体、隔膜和大脑皮层中观察到 5-HT1A 位点的密度逐渐增加，直至出生后第三周左右达到成人水平。相比之下，在其他结构（例如外侧丘系核）中注意到复杂的双相（先增加然后减少）变化，甚至在出生后的前两周内，小脑中 5-HT1A 位点的密度也发生了逐渐减少。 5-HT1A 受体结合位点在小脑等专门为产后发育的结构中的瞬时表达进一步支持 5-HT 可能在中枢神经系统成熟过程中发挥营养作用。
The developmental evolution of 5-HT1A receptor binding sites was examined in the rat CNS during the early postnatal period using quantitative autoradiography and binding assays with 3H-8-OH-DPAT as the selective ligand. A progressive increase in the density of 5-HT1A sites was observed in the hippocampus, septum and cerebral cortex, up to adult levels which were reached around the third postnatal week. In contrast, complex biphasic (increase then decrease) changes were noted in other structures (for instance the nucleus of the lateral lemniscus), and even a progressive decrease in the density 5-HT1A sites took place in the cerebellum during the first two postnatal weeks. The transient expression of 5-HT1A receptor binding sites in a structure such as the cerebellum which developes exclusively for the postnatal period further supports that 5-HT might play a trophic role during maturation of the CNS.