Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells
Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells
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DOI：
10.1263/jbb.105.679
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发表时间：
2008-06-01
影响因子：
2.8
通讯作者：
Kamihira, Masamichi
中科院分区：
文献类型：
--
作者：
Ito, Akira;Kiyohara, Takehiko;Kamihira, Masamichi
上皮细胞粘附分子E-cadherin在NIH 3 T3成纤维细胞中表达，并且角质形成细胞和成纤维细胞之间或肝细胞和成纤维细胞之间的细胞-细胞相互作用是人工设计的。当表达E-cadherin的NIH 3 T3细胞与大鼠肝细胞共培养时，以高频率形成细胞-细胞接触，并观察到增强的白蛋白分泌。
An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.