Physiology and cell biology update: polypeptide growth factors and their relation to renal disease.
Physiology and cell biology update: polypeptide growth factors and their relation to renal disease.
复制标题
生理学和细胞生物学更新：多肽生长因子及其与肾脏疾病的关系。
DOI：
10.1016/s0272-6386(89)80096-4
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Fine,LG
中科院分区：
文献类型：
--
作者：
Kujubu,DA;Fine,LG
许多多肽生长因子已被证明可作用于不同类型的肾细胞，其中许多是由肾脏本身产生的。目前尚不清楚肾单位破坏后的代偿性肥大是否受到生长因子的控制，但它们无疑参与了各种形式的进行性肾损伤，包括通过自分泌、旁分泌甚至可能内分泌途径引起的慢性肾小球和肾小管间质疾病。随着这个快速变化的领域出现新的发展，人们希望这些知识可以用来减轻损害、阻止进展或促进肾脏和其他组织疾病过程的恢复。
A number of polypeptide growth factors have been shown to act on different types of renal cells, and many are produced by the kidney itself. It is unclear whether the compensatory hypertrophy that follows the destruction of nephrons is under the control of growth factors, but they undoubtedly participate in various forms of progressive renal injury, including chronic glomerular and tubulointerstitial diseases via autocrine, paracrine, and possibly even endocrine routes. As new developments occur in this rapidly changing field, it is hoped that this knowledge can be used to ameliorate the damage, halt the progression, or enhance the recovery from a disease process in the kidney and in other tissues.