Immunohistopathology of lymph nodes in HTLV-III infected homosexuals with persistent adenopathy or AIDS.
Immunohistopathology of lymph nodes in HTLV-III infected homosexuals with persistent adenopathy or AIDS.
复制标题
HTLV-III 感染且患有持续性淋巴结病或艾滋病的同性恋者的淋巴结免疫组织病理学。
作者：
P. Biberfeld;A. PORWIT‐KSIAZEK;B. Böttiger;L. Morfeldt;G. Biberfeld
淋巴结活检从43名男性同性恋者与持续性全身淋巴结病和10名获得性免疫缺陷综合征患者，所有血清抗体的人T细胞白血病病毒III，进行了研究方面的组织病理学，免疫组织学和T细胞亚群的细胞悬液。所有获得性免疫缺陷综合征活检，除了一个卡波西肉瘤有相同的组织病理学模式的滤泡耗竭，而持续性全身淋巴结病的节点表现出一系列的变化，其特征是滤泡增生，退化与滤泡碎片，或退化与滤泡萎缩。免疫组织学显示滤泡退化、滤泡树突状网状细胞消失和T细胞侵入滤泡之间存在时间和结构关系。这些观察结果表明，消除树突状网状细胞的一部分，在卵泡退化的致病机制。血管生成测量染色的内皮细胞与抗体的因子VIII增加，在许多活检的退化和消耗阶段。我们的观察表明，发生显着的变化，不仅在T细胞，而且在B细胞室的患者持续全身淋巴结病或获得性免疫缺陷综合征。结合组织病理学和免疫组化的可能性分期这些患者的淋巴结。这可能会改善这些患者的预后评估。血管生成的卡波西肉瘤的肿瘤发生的可能重要性的建议。
Lymph node biopsies from 43 male homosexuals with persistent generalized lymphadenopathy and from ten acquired immunodeficiency syndrome patients, all with serum antibodies to human T-cell leukemia virus III, were studied with regard to histopathology, immunohistology, and T-cell subsets in cell suspensions. All acquired immunodeficiency syndrome biopsies except one with Kaposi's sarcoma had the same histopathological pattern of follicular depletion, whereas the persistent generalized lymphadenopathy nodes showed a spectrum of changes characterized as follicular hyperplasia, involution with follicular fragmentation, or involution with follicular atrophy. Immunohistology showed a temporal and structural relation between follicular involution, disappearance of follicular dendritic reticulum cells, and follicular invasion by T-cells. These observations suggest elimination of dendritic reticulum cells as part of a pathogenic mechanism in follicular involution. Angiogenesis measured by staining of endothelial cells with antibodies to Factor VIII was increased in many biopsies in stages of involution and depletion. Our observations indicate the occurrence of marked changes not only in T-cells but also in the B-cell compartment of patients with persistent generalized lymphadenopathy or acquired immunodeficiency syndrome. The possibility of staging lymph nodes of these patients by combined histopathology and immunohistology is indicated. This might improve the evaluation of prognosis in these patients. A possible importance of angiogenesis for the tumorigenesis of Kaposi's sarcoma is suggested.