Immunophenotypic characterization of lymphoid cell infiltrates in vitiligo
Immunophenotypic characterization of lymphoid cell infiltrates in vitiligo
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DOI：
10.1111/cei.12096
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发表时间：
2013-08-01
影响因子：
4.6
通讯作者：
Ruiz-Argueelles, A.
中科院分区：
文献类型：
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作者：
Sanchez-Sosa, S.;Aguirre-Lombardo, M.;Ruiz-Argueelles, A.
白癜风的发病机制仍有争议。本研究的目的是深入了解淋巴样细胞浸润白癜风皮肤脱色区域的性质。对20例活动性病变患者的活检进行免疫化学检查，寻找表达CD1a、CD2、CD3、CD4、CD5、CD8、CD20、CD25、CD30、CD56、CD68和CD79a的细胞。结果表明，早期病变主要由树突状细胞浸润，而老年病变中树突状细胞的比例明显降低，成熟T细胞的比例增加。这一发现可能提示对黑素细胞抗原的自身免疫反应性可能是T细胞依赖和抗原驱动的。可能是黑素细胞的非免疫攻击导致了细胞内抗原的暴露，而自身反应性可能是继发性的、自我延续的机制。
The pathogenesis of vitiligo is still controversial. The purpose of this study was to gain insight into the nature of lymphoid cells infiltrating depigmented areas of skin in vitiligo. Immunochemical procedures were carried out in biopsies from 20 patients with active lesions to search for cells expressing CD1a, CD2, CD3, CD4, CD5, CD8, CD20, CD25, CD30, CD56, CD68 and CD79a. Results indicate that early lesions are infiltrated mainly by dendritic cells, whereas older lesions display significantly lower proportions of these cells and increased percentages of mature T cells. This finding might suggest that the autoimmune reactivity towards melanocyte antigens might be T cell-dependent and antigen-driven. It is possible that a non-immune offence of melanocytes is responsible for the exposure of intracellular antigens, while autoreactivity might be a secondary, self-perpetuating mechanism.