Comparison of endothelial function evaluated by strain gauge plethysmography and brachial artery ultrasound
Comparison of endothelial function evaluated by strain gauge plethysmography and brachial artery ultrasound
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DOI：
10.1016/s0021-9150(01)00406-3
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发表时间：
2001-09-01
期刊：
影响因子：
5.3
通讯作者：
Gnasso, A
中科院分区：
文献类型：
--
作者：
Irace, C;Ceravolo, R;Gnasso, A
应变式脉搏波和肱动脉超声被广泛用于研究血管内皮功能。没有关于这两种手术之间相关性的数据报道。本研究比较了这两种方法，探讨了血管舒张与臂壁剪应力的关系。对6名健康受试者和10名高血压或肥胖患者在静息状态和输注7.5、15和30马克杯/分钟乙酰胆碱后进行应变计体积描记，在静息状态和手部缺血5分钟后进行肱动脉超声。壁面剪切应力计算为：血液黏度x血流速度/内径。健康受试者注射乙酰胆碱后前臂血流量比高血压或肥胖患者增加更多。此外，前一组肱动脉扩张更明显。臂动脉直径变化与前臂血流量变化相关，以乙酰胆碱灌注曲线下面积计算（r = 0.739, P < 0.001）。健康受试者的壁剪应力（67.8 +/- 20.0 dynes/cm(2)）高于高血压或肥胖患者（39.2 +/- 16.7,P < 0.001），且与管径变化相关（r = 0.796, P < 0.0002），与血流变化无关（r = 0.516, P < 0.05）。目前的研究结果表明，应变计体积脉搏图和肱动脉超声评估的内皮功能之间存在高度相关性。壁剪应力与手缺血后肱动脉直径变化相关，与乙酰胆碱输注后血流量变化相关。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Strain gauge plethysmography and brachial artery ultrasound are widely used to study endothelial function. No data on correlation between these two procedures are reported. The present study compared these two methods and investigated the correlation between vasodilation and brachial wall shear stress. In six healthy subjects and ten patients with hypertension or obesity, strain gauge plethysmography was performed in resting conditions and after infusion of 7.5, 15 and 30 mug/min of acetylcholine, and brachial artery ultrasound in resting conditions and after 5 min hand ischemia. Wall shear stress was calculated as: blood viscosity x blood velocity/internal diameter. Forearm blood flow following acetylcholine infusion increased more in healthy subjects than in patients with hypertension or obesity. In addition, brachial artery dilated more in the former group. Change in brachial artery diameter correlated with change in forearm blood flow, calculated as area under the curve of acetylcholine infusion (r = 0.739, P < 0.001). Wall shear stress was higher in healthy subjects (67.8 +/- 20.0 dynes/cm(2)) than in patients with either hypertension or obesity (39.2 +/- 16.7, P < 0.001), and correlated with variations of diameter (r = 0.796, P < 0.0002), and marginally of blood flow (r = 0.516, P < 0.05). The present findings demonstrate that there is a high correlation between endothelial function evaluated by strain gauge plethysmography and brachial artery ultrasound. Wall shear stress correlates with brachial artery diameter change following hand ischemia, and marginally with blood flow change following acetylcholine infusion. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.