From genetics of inflammatory bowel disease towards mechanistic insights.
From genetics of inflammatory bowel disease towards mechanistic insights.
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DOI：
10.1016/j.it.2013.04.001
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发表时间：
2013-08
影响因子：
16.8
通讯作者：
Xavier RJ
中科院分区：
文献类型：
--
作者：
Graham DB;Xavier RJ
Advancements in human genetics now poise the field to illuminate the pathophysiology of complex genetic disease. In particular, genome-wide association studies have generated insights into the mechanisms driving inflammatory bowel disease (IBD) and implicated genes shared by multiple autoimmune and autoinflammatory diseases. Thus, emerging evidence suggests a central role for the mucosal immune system in mediating immune homeostasis and highlights the complexity of genetic and environmental interactions that collectively modulate risk of disease. Nevertheless, the challenge remains to determine how genetic variation can precipitate and sustain the inappropriate inflammatory response to commensals that is observed in IBD. Here, we highlight recent advancements in immunogenetics and provide a forward-looking view of the innovations that will deliver mechanistic insights from human genetics.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
7.7
作者：
Gerold KD;Zheng P;Rainbow DB;Zernecke A;Wicker LS;Kissler S
通讯作者：
Kissler S
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.1103746
发表时间：
2012-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Conway KL;Goel G;Sokol H;Manocha M;Mizoguchi E;Terhorst C;Bhan AK;Gardet A;Xavier RJ
通讯作者：
Xavier RJ
影响因子：
64.5
作者：
Gomez JA;Wapinski OL;Yang YW;Bureau JF;Gopinath S;Monack DM;Chang HY;Brahic M;Kirkegaard K
通讯作者：
Kirkegaard K