β-PNA: peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone.
β-PNA: peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone.
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DOI：
10.1016/j.bmcl.2011.10.017
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发表时间：
2011-12
影响因子：
2.7
通讯作者：
T. Sugiyama;Y. Imamura;Yosuke Demizu;M. Kurihara;M. Takano;A. Kittaka
中科院分区：
文献类型：
--
作者：
T. Sugiyama;Y. Imamura;Yosuke Demizu;M. Kurihara;M. Takano;A. Kittaka
合成了在β位置有甲基的肽核酸（PNA）单体。用Fmoc化学方法将改性单体掺入PNA低聚物中进行固相合成。热变性和圆二色性（CD）研究表明，含有s型单体的PNA很适合与DNA形成杂交双相，其稳定性与未修饰的PNA - DNA双相相当，而含有r型单体的PNA则不适合。
Peptide nucleic acid (PNA) monomers with a methyl group at the β-position have been synthesized. The modified monomers were incorporated into PNA oligomers using Fmoc chemistry for solid-phase synthesis. Thermal denaturation and circular dichroism (CD) studies have shown that PNA containing the S-form monomers was well suited to form a hybrid duplex with DNA, whose stability was comparable to that of unmodified PNA–DNA duplex, whereas PNA containing the R-form monomers was not.