Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder
Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder
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DOI：
10.1186/s12888-020-02841-4
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发表时间：
2020-09-04
期刊：
影响因子：
4.4
通讯作者：
Hirano, Yoshiyuki
中科院分区：
文献类型：
--
作者：
Hamatani, Sayo;Tsuchiyagaito, Aki;Hirano, Yoshiyuki
研究背景认知行为疗法（CBT）包括暴露和反应预防（ERP），对改善强迫症（OCD）症状有效。然而，认知功能差和自闭症谱系障碍（ASD）特征是否会影响强迫症患者对基于ERP的CBT的治疗反应仍不清楚。本研究旨在确定因素预测的治疗反应的日本强迫症患者的ERP为基础的CBT。MethodsForty 2日本门诊强迫症患者进行了评估，使用韦氏成人智力量表-III（WAIS-III），耶鲁-布朗强迫量表，患者健康问卷9项规模，自闭症谱系商数（AQ）在治疗前和治疗后。我们使用多元回归分析来估计对治疗反应变化的影响。治疗反应的变化被设置为多元回归分析中的因变量。ResultsMultiple regression analysis.ResultsMultiple regression analyses表明，在自变量中，沟通作为AQ子量表和字母编号排序作为WAIS-III子测试预测基于ERP的CBT的治疗反应。（字母数字排序），沟通技巧差（AQ分量表）可能会破坏强迫症患者对基于ERP的CBT的反应。2016年9月20日注册-回顾性注册（包括回顾性数据）。
BackgroundCognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT.MethodsForty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses.ResultsMultiple regression analyses showed that among independent variables, communication as an AQ sub-scale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT .ConclusionsOur results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD.Trial registrationUMIN, UMIN00024087. Registered 20 September 2016 - Retrospectively registered (including retrospective data).