INVIVO BEHAVIOR OF POLYMERIZED LIPID VESICLES
INVIVO BEHAVIOR OF POLYMERIZED LIPID VESICLES
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DOI：
10.1002/jps.2600760102
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发表时间：
1987-01-01
影响因子：
3.8
通讯作者：
REGEN, S
中科院分区：
文献类型：
--
作者：
KRAUSE, HJ;JULIANO, RL;REGEN, S
我们研究了由光聚合脂质[12-（甲基丙烯酰氧基）十二烷基]- l - α -磷脂酰胆碱组成的大多层脂质体（MLVs）和小单层脂质体（suv）的血液清除动力学和组织分布。聚合的mlv或suv比具有相似大小的非聚合囊泡更快地从血液中清除。聚合和非聚合囊泡主要积聚在肝脏和脾脏。然而，聚合囊泡表现出增强的生物稳定性，这是由组织中残留的放射性脂质标记物水平升高所揭示的。
We have investigated the blood clearance kinetics and tissue distribution of large multilamellar liposomes (MLVs) and small unilamellar liposomes (SUVs) composed of the photopolymerizable lipid bis[12-(methacryloyloxy)dodecanoyl]-L-.alpha.-phosphatidylcholine. Polymerized MLVs or SUVs are cleared from the bloodstream more rapidly than nonpolymerized vesicles with similar size profiles. Both polymerized and nonpolymerized vesicles primarily accumulate in liver and spleen. However, the polymerized vesicles display an enhanced biostability as revealed by an elevated level of radioactive lipid marker remaining in the tissues.