MicroRNAs as Biomarkers for Myocardial Infarction
MicroRNAs as Biomarkers for Myocardial Infarction
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DOI：
10.1007/s11883-012-0238-z
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发表时间：
2012-06-01
影响因子：
5.8
通讯作者：
De Windt, Leon J.
中科院分区：
文献类型：
--
作者：
Salic, Kanita;De Windt, Leon J.
MicroRNA (miR) 是短的非编码 RNA 分子，通过与信使 RNA (mRNA) 的 3' 非翻译区结合来参与转录后基因调控，从而抑制翻译或诱导 mRNA 不稳定。 MiR 通常被认为是正常心脏功能所必需的细胞内介质，其表达失调与心血管疾病有关。最近的研究表明，人外周血中存在自由循环的 miR，且其稳定存在。这提出了 miR 可能在循环中释放并可作为急性或慢性人类疾病（包括心肌梗塞（MI））的新型诊断标记物的可能性。本综述总结了满足 MI 候选生物标志物标准的 miR 的最新发现。
MicroRNAs (miRs) are short non-coding RNA molecules involved in post-transcriptional gene regulation by binding to the 3' untranslated region of a messenger RNA (mRNA), thereby inhibiting the translation or inducing mRNA destabilization. MiRs are generally considered to act as intracellular mediators essential for normal cardiac function, and their deregulated expression profiles have been associated with cardiovascular diseases. Recent studies have revealed the existence of freely circulating miRs in human peripheral blood, which are present in a stable nature. This has raised the possibility that miRs may be released in the circulation and can serve as novel diagnostic markers for acute or chronic human disorders, including myocardial infarction (MI). This review summarizes the recent findings of miRs that fulfill the criteria of candidate biomarkers for MI.