Sampling behavior in the radial maze and operant chamber: role of the hippocampus and prefrontal area.

Sampling behavior in the radial maze and operant chamber: role of the hippocampus and prefrontal area.
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径向迷宫和操作室中的采样行为:海马体和前额叶区域的作用。

DOI:
10.1037//0735-7044.102.4.489
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发表时间:
1988
影响因子:
1.9
通讯作者:
Stidham,JA
Stidham,JA
中科院分区:
医学4区
文献类型:
--
作者:
Devenport,LD;Hale,RL;Stidham,JA

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在放射状迷宫和操作环境中观察老鼠,在一定限度内不可能犯“错误”。在这种情况下,如果动物愿意的话,他们可以通过改变自己的行为来自由地从环境中寻求信息,而不会受到无奖励的惩罚。海马体受损但前额叶或顶叶未受损的老鼠在迷宫中的连续手臂选择较少,并且对迷宫及其环境的感觉分析大大减少。在配备多个杠杆的操作室中,只有海马病变缩小了反应间隔的变化,从而导致节律性反应。相反,三个反应目标的反应分布不受中枢神经系统损伤的影响。海马病变造成的这种信息剥夺模式与此类动物在依赖此类信息以获得最佳表现的更常规任务中的表现相似。重要的是,采样缺陷并不是海马损伤的直接结果。仔细观察发现,僵化随着时间的推移而发展,尽管速度相当快。因此,海马切除术后行为变化的缩小取决于任务体验的某些交互成分。我们认为奖励是另一个关键因素。
Rats were observed in the radial maze and in an operant setting where “errors” were, within limits, impossible to commit. Under these circumstances, the animals were free to seek information from the environment by varying their behavior, if they chose to do so, without penalty of nonreward. Rats with hippocampal, but not prefrontal or parietal damage, sampled fewer successive arm choices in the maze and exhibited a greatly reduced sensory analysis of the maze and its context. In operant chambers equipped with multiple levers, only hippocampal lesions narrowed the variety of interresponse intervals, which resulted in rhythmic responding. In contrast, the distribution of responses across the three response targets was not influenced by central nervous system injury. This pattern of information deprivation imposed by the hippocampal lesion parallels the profile of performance of such animals on more conventional tasks that depend on such information for optimal performance. Importantly, the sampling deficits were not direct outcomes of the hippocampal damage. Close scrutiny revealed that the rigidity developed over time, albeit quite rapidly. Thus the narrowed behavioral variation following hippocampectomy depends on some interactive component of task experience. We argue that reward is the other critical ingredient.
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