Ardeemins and citrinin dimer derivatives from Aspergillus terreus harbored in Pinellia ternate
Ardeemins and citrinin dimer derivatives from Aspergillus terreus harbored in Pinellia ternate
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半夏中土曲霉的 Ardeemins 和 citrinin 二聚体衍生物
DOI：
10.1016/j.phytol.2021.02.007
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发表时间：
2021-02-22
影响因子：
1.7
通讯作者：
Kong, Ling-Yi
中科院分区：
文献类型：
--
作者：
Gu, Liang;Sun, Fu-Juan;Kong, Ling-Yi
从半夏内生土曲霉的固体培养物中分离出一种新的生物碱 15b-β-羟基-16β-羟基-5-N-乙酰阿胺 (1) 和一种新的柠檬酸二聚体衍生物青三醇 Q (5)，以及三种已知的生物碱 (2?4) 和两种柠檬酸二聚体 (6?7)。通过详细的光谱分析确定了它们的结构，并通过单晶X射线衍射和ECD光谱的比较确定了绝对构型。 Penicitrinol Q (5) 对金黄色葡萄球菌和枯草芽孢杆菌具有抑制作用，MIC50 值分别为 4.3 和 6.2 μg/mL。当使用30μM的浓度时，化合物2在治疗阿霉素耐药的人乳腺癌细胞系中显示出阿霉素敏感性增强2.1倍。
One new alkaloid, 15b-?-hydroxy-16?-hydroxy-5-N-acetylardeemin (1), and one new dimeric derivative of citrinin, penicitrinol Q (5), together with three known alkaloids (2?4) and two citrinin dimers (6?7), were isolated from the solid culture of an endophytic Aspergillus terreus resided in Pinellia ternata. Their structures were established by detailed spectroscopic analysis, and the absolute configurations were determined by single crystal X?ray diffraction and the comparison of ECD spectra. Penicitrinol Q (5) exhibited inhibitory effects against Staphylococcus aureus and Bacillus subtilis with MIC50 values of 4.3 and 6.2 ?g/mL, respectively. When using a concentration of 30 ?M, compound 2 showed 2.1-fold enhancement of doxorubicin susceptibility in treating doxorubicin-resistant human breast cancer cell line.