Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia
Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia
复制标题
DOI：
10.1016/0006-8993(91)90784-s
复制
发表时间：
1991-09
期刊：
影响因子：
2.9
通讯作者：
M. Lyons;Robert E. Anderson;F. Meyer
中科院分区：
文献类型：
--
作者：
M. Lyons;Robert E. Anderson;F. Meyer
本实验旨在确定在轻度慢性前脑缺血模型中，脑室内给予碱性成纤维细胞生长因子（bFGF）是否可以促进脑血管生成。Wistar大鼠双侧颈总动脉结扎。动物接受脑室内注射bFGF，每4天一次，共28天。碱性成纤维细胞生长因子引起了显着的剂量依赖性增加毛细血管密度相比，缺血控制在所有地区检查。这些结果支持的假设，慢性脑室内注射bFGF诱导在体内脑血管生成。
This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.