GENETIC-RESISTANCE TO FOWL CHOLERA IS LINKED TO THE MAJOR HISTOCOMPATIBILITY COMPLEX
GENETIC-RESISTANCE TO FOWL CHOLERA IS LINKED TO THE MAJOR HISTOCOMPATIBILITY COMPLEX
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DOI：
10.1007/bf00404420
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发表时间：
1987-01-01
期刊：
影响因子：
3.2
通讯作者：
CHEVILLE, N
中科院分区：
文献类型：
--
作者：
LAMONT, SJ;BOLIN, C;CHEVILLE, N
选择爱荷华州S1系的鸡，因为它们具有还原鲁斯肉瘤病毒（RSV）肿瘤的能力，对GAT （Ir-GAT）和红细胞抗原b的体液免疫反应，主要组织相容性复合体（MHC）的亚系纯合子，以及F1杂合子和F2分离子，用多杀性巴氏杆菌X73菌株攻毒，测试了鸡对家禽霍乱的抗性。在一项初步研究中，高剂量的反应控制与Ir-GAT和对RSV肿瘤的反应有关。通过亚系和F2分离体与B-G区基因的关联，证明了对低剂量多杀线虫抗性的遗传控制。因此，暴露于多杀性巴氏杆菌后的鸡对禽霍乱抗性的遗传控制被证明与主要的组织相容性B复合体有关，这是mhc对细菌性疾病挑战抗性的首次证明。
Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for resistance to fowl cholera by challenge with Pasteurella multocida strain X73. Control of the response at high doses was associated in a preliminary study with Ir-GAT and response to RSV tumors. Genetic control of resistance to low doses of P. multocida was demonstrated via sublines and F2 segregants to be linked with genes of the B-G region. Thus, genetic control of resistance to fowl cholera in chickens after exposure to Pasteurella multocida was shown to be linked to the major histocompatibility B complex, in this first demonstration of MHC-linked resistance to bacterial disease challenge.