Synchrotron-radiation phase-contrast imaging of human stomach and gastric cancer: in vitro studies
Synchrotron-radiation phase-contrast imaging of human stomach and gastric cancer: in vitro studies
复制标题
人胃和胃癌的同步辐射相衬成像：体外研究
DOI：
10.1107/s090904951200310x
复制
发表时间：
2012-05-01
影响因子：
2.5
通讯作者：
Zhang, Xiao-Peng
中科院分区：
文献类型：
--
作者：
Tang, Lei;Li, Gang;Zhang, Xiao-Peng
同步辐射相位衬度成像（SR-PCI）的电子密度分辨率比传统的X射线吸收成像高1000倍，可以实现生物软组织的高分辨率X射线成像。对于生物软组织，SR-PCI可以提供比常规X射线吸收成像更好的成像对比度。在北京同步辐射装置4 W1 A光束线上，利用同轴全息和衍射增强成像技术对人体胃和胃癌进行了研究。SR-PCI可以显示胃小凹（5070 μ m）、胃沟和粘膜下层的微小血管。癌性溃疡的细微结构在粘膜成像上显示得很清楚。胃壁分层和癌细胞浸润在粘膜下层也表现在横断面成像上。结论：SR-PCI能显示常规X线吸收成像所不能显示的胃及胃癌的细微结构，将胃部疾病的X线诊断提高到胃小凹水平，有望为胃癌的影像学诊断提供新的方法。
The electron density resolution of synchrotron-radiation phase-contrast imaging (SR-PCI) is 1000 times higher than that of conventional X-ray absorption imaging in light elements, through which high-resolution X-ray imaging of biological soft tissue can be achieved. For biological soft tissue, SR-PCI can give better imaging contrast than conventional X-ray absorption imaging. In this study, human resected stomach and gastric cancer were investigated using in-line holography and diffraction enhanced imaging at beamline 4W1A of the Beijing Synchrotron Radiation Facility. It was possible to depict gastric pits, measuring 5070 mu m, gastric grooves and tiny blood vessels in the submucosa layer by SR-PCI. The fine structure of a cancerous ulcer was displayed clearly on imaging the mucosa. The delamination of the gastric wall and infiltration of cancer in the submucosa layer were also demonstrated on cross-sectional imaging. In conclusion, SR-PCI can demonstrate the subtle structures of stomach and gastric cancer that cannot be detected by conventional X-ray absorption imaging, which prompt the X-ray diagnosis of gastric disease to the level of the gastric pit, and has the potential to provide new methods for the imageology of gastric cancer.