STROGAR - STrengthening the Reporting Of Genetic Association studies in Radiogenomics.
STROGAR - STrengthening the Reporting Of Genetic Association studies in Radiogenomics.
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DOI：
10.1016/j.radonc.2013.07.011
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Bentzen SM
中科院分区：
文献类型：
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作者：
Kerns SL;de Ruysscher D;Andreassen CN;Azria D;Barnett GC;Chang-Claude J;Davidson S;Deasy JO;Dunning AM;Ostrer H;Rosenstein BS;West CM;Bentzen SM
尽管迄今为止发表了大量的放射基因组学研究，但在独立的验证研究中很少重现阳性单核苷酸多态性（SNP）相关性。这些不一致的一个主要原因是大量的假阳性结果，因为没有对多重比较进行调整。由于方法学缺陷或未能重现原始研究的相关细节，一些验证研究也可能是假阴性。需要透明的报告，以确保这些缺陷不会阻碍放射基因组学的进展。为了满足提高该领域研究质量的需要，放射基因组学联合会编制了一份18项清单，用于报告放射基因组学研究。人们认识到，并非所有研究都记录了清单中包含的所有信息。但是，作者应报告所有检查表项目，并确认任何缺失的信息。使用STROGAR指南将通过增加报告的透明度和完整性来推进放射基因组学领域。
Despite publication of numerous radiogenomics studies to date, positive single nucleotide polymorphism (SNP) associations have rarely been reproduced in independent validation studies. A major reason for these inconsistencies is a high number of false positive findings because no adjustments were made for multiple comparisons. It is also possible that some validation studies were false negatives due to methodological shortcomings or a failure to reproduce relevant details of the original study. Transparent reporting is needed to ensure these flaws do not hamper progress in radiogenomics. In response to the need for improving the quality of research in the area, the Radiogenomics Consortium produced an 18-item checklist for reporting radiogenomics studies. It is recognised that not all studies will have recorded all of the information included in the checklist. However, authors should report on all checklist items and acknowledge any missing information. Use of STROGAR guidelines will advance the field of radiogenomics by increasing the transparency and completeness of reporting.