Photolytic Release of a Caged Inhibitor of an Endogenous Transcription Factor Enables Optochemical Control of CREB-Mediated Gene Expression
Photolytic Release of a Caged Inhibitor of an Endogenous Transcription Factor Enables Optochemical Control of CREB-Mediated Gene Expression
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DOI：
10.1021/acs.orglett.9b03568
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发表时间：
2020-01-03
期刊：
影响因子：
5.2
通讯作者：
Kikuchi, Kazuya
中科院分区：
文献类型：
--
作者：
Imoto, Takuma;Kawase, Akihiro;Kikuchi, Kazuya
已经开发了一种用于调节基因功能的直接光化学方法，该方法基于无活性的笼状前体的解开，该笼状前体片段化以产生CREB（cAMP-反应元件结合蛋白）抑制剂，该抑制剂结合负责调节CREB介导的基因表达水平的内源性转录因子。
A direct optochemical method for regulating gene function has been developed based on uncaging of an inactive caged precursor that fragments to produce a CREB (CAMP-response element binding protein) inhibitor that binds to an endogenous transcription factor responsible for regulating CREB-mediated gene expression levels.