Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging
Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging
复制标题
采用传统 X 射线管和光子计数探测器的全场扇形束 X 射线荧光计算机断层扫描，用于快速纳米颗粒生物成像
DOI：
10.1117/1.oe.56.4.043106
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发表时间：
2017-04-01
影响因子：
1.3
通讯作者：
Chen, Zhiqiang
中科院分区：
文献类型：
--
作者：
Li, Liang;Zhang, Siyuan;Chen, Zhiqiang
抽象的。由于X射线荧光光子的发射和检测效率低，X射线荧光计算机断层扫描（XFCT）是在高强度同步辐射源或具有长曝光时间的笔形光束上进行的。首次提出了采用光子计数探测器阵列的全视场扇束XFCT的可行性和实验结果。该全视场扇束XFCT由常规低强度X射线管、能量敏感光子计数探测器阵列和钨针孔准直器组成。使用多色X射线扇形射束和第三代计算机断层扫描（CT）几何结构扫描含钆溶液（Kα，42.74 keV）的体模30 min。经过散射和衰减校正后，实验结果表明，XFCT比光谱CT具有更好的精度和性能。全视野XFCT是一种很有前途的生物医学成像模式的外源分子探针含有高原子序数的纳米粒子。
Abstract. X-ray fluorescence computed tomography (XFCT) was performed on a high-intensity synchrotron radiation source or a pencil beam with a long exposure time due to the low emission and detection efficiency of x-ray fluorescence photons. For the first time, the feasibility and experimental results of a full-field fan-beam XFCT with a photon-counting detector array are presented. This full-field fan-beam XFCT consists of a conventional low-intensity x-ray tube, an energy-sensitive photon-counting detector array, and a tungsten pinhole collimator. A phantom containing gadolinium solution (Kα, 42.74 keV) was scanned for 30 min using a polychromatic x-ray fan beam with a third-generation computed tomography (CT) geometry. After scattering and attenuation corrections, experimental results showed that XFCT had better accuracy and performance than spectral CT. Full-field XFCT is a promising modality for biomedical imaging of exogenous molecular probes containing nanoparticles of high atomic number.