Personality traits and brain dopaminergic function in Parkinson's disease
Personality traits and brain dopaminergic function in Parkinson's disease
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DOI：
10.1073/pnas.231313198
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发表时间：
2001-11-06
影响因子：
11.1
通讯作者：
Rinne, JO
中科院分区：
文献类型：
--
作者：
Kaasinen, V;Nurmi, E;Rinne, JO
一种独特的人格类型，其特征是内向，易变性和低新奇寻求，已被认为与帕金森病有关。为了验证帕金森病与特定多巴胺相关人格类型相关的假设，对61名未服药的帕金森病患者和45名健康对照者的人格结构进行了检查。此外，在47名帕金森病患者中，用6-[F-18]氟-L-多巴（F-18-dopa）正电子发射断层扫描（PET）与MRI共配准直接测量脑中的多巴胺能功能。与对照组相比，帕金森病组的猎奇性人格得分（被认为与帕金森病人格有关）略低，但与研究的任何脑区的F-18-多巴摄取量均无显著关系（r = -0.12至0.11，P > 0.15）。与焦虑和抑郁相关的伤害回避人格评分在帕金森病患者中明显增加，并且与右侧尾状核中的F-18-多巴摄取存在矛盾的、高度显著的正相关性（r = 0.53，P = 0.04，Bonferroni校正了220次比较）。虽然本研究的结果与帕金森氏病中低新奇寻求人格类型的概念并不矛盾，但这种人格类型似乎并不依赖于多巴胺。避免伤害的人格特质和F-18-多巴之间的相关性可能反映了与帕金森病中的负面情绪相关的神经递质的特定反馈回路。
A distinctive personality type, characterized by introversion, inflexibility, and low novelty seeking, has been suggested to be associated with Parkinson's disease. To test the hypothesis that Parkinson's disease is associated with a specific dopamine-related personality type, the personality structures of 61 unmedicated Parkinson's disease patients and 45 healthy controls were examined. Additionally, in 47 Parkinson's disease patients, the dopaminergic function in the brain was directly measured with 6-[F-18]fluoro-L-dopa (F-18-dopa) positron emission tomography (PET) with MRI coregistration. The novelty-seeking personality score, supposedly associated with the parkinsonian personality, was slightly lower in the Parkinson's disease group compared with controls, but it did not have a significant relationship with F-18-dopa uptake in any of the brain regions studied (r = -0.12 to 0.11, P > 0.15). The harm-avoidance personality score, associated with anxiety and depression, was clearly increased in patients with Parkinson's disease and it had a paradoxical, highly significant positive correlation with the F-18-dopa uptake in the right caudate nucleus (r = 0.53, P = 0.04, Bonferroni corrected for 220 comparisons). Although the results of this study are not in disagreement with the concept of low-novelty-seeking personality type in Parkinson's disease, the personality type does not seem to be dopamine dependent. The correlation between the personality trait of harm avoidance and F-18-dopa may reflect a specific feedback circuitry of neurotransmitters that is associated with negative emotionality in Parkinson's disease.