Relationship between C-reactive protein and glucose levels in community-dwelling subjects without diabetes - The Hisayama Study
Relationship between C-reactive protein and glucose levels in community-dwelling subjects without diabetes - The Hisayama Study
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DOI：
10.2337/diacare.28.5.1211
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发表时间：
2005-05-01
期刊：
影响因子：
16.2
通讯作者：
Iida, M
中科院分区：
文献类型：
--
作者：
Doi, Y;Kiyohara, Y;Iida, M
C反应蛋白（CRP）是全身炎症的标志物，正在成为心血管疾病的独立风险因素（1，2）。也有报道称，糖耐量受损（IGT）（3）或糖尿病（4）患者的血清CRP水平升高。一些前瞻性研究表明，CRP水平升高是未来糖尿病的独立风险因素（5，6）。尽管这些发现表明外周血中CRP水平与血糖水平密切相关，但尚不清楚CRP水平与糖尿病前期范围内的血糖水平之间是否存在关系。本研究的目的是调查一般日本人群中CRP浓度与糖尿病前期血糖水平之间的关系。
C-reactive protein (CRP), a marker of systemic inflammation, is emerging as an independent risk factor for cardiovascular disease (1,2). It has also been reported that serum CRP levels are elevated in patients with impaired glucose tolerance (IGT) (3) or diabetes (4). A few prospective studies have shown that increased CRP levels are an independent risk factor for future diabetes (5,6). Although these findings indicate that CRP levels in peripheral blood are closely associated with glucose levels, it remains unclear whether a relationship exists between CRP levels and plasma glucose levels in the pre-diabetic range. The purpose of the present study was to investigate the relationship between CRP concentrations and pre-diabetic plasma glucose levels in a general Japanese population.