Involvement of pertussis toxin-sensitive GTP-binding protein in prostaglandin F2 alpha- induced phosphoinositide hydrolysis in osteoblast-like cells.

Involvement of pertussis toxin-sensitive GTP-binding protein in prostaglandin F2 alpha- induced phosphoinositide hydrolysis in osteoblast-like cells.
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百日咳毒素敏感 GTP 结合蛋白参与前列腺素 F2 α 诱导的成骨细胞样细胞中磷酸肌醇水解。

DOI:
10.1016/0006-291x(90)90817-7
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发表时间:
1990
影响因子:
3.1
通讯作者:
Yutaka Oiso
Yutaka Oiso
中科院分区:
生物学4区
文献类型:
--
作者:
M. Miwa;H. Tokuda;K. Tsushita;J. Kotoyori;Y. Takahashi;N. Ozaki;O. Kozawa;Yutaka Oiso

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Prostaglandin F2α(PGF2α) stimulated the formation of inositol phosphates in a dose-dependent manner in cloned osteoblast-like MC3T3-E1 cells. This reaction was markedly inhibited dose-dependently by pertussis toxin. In the cell membranes, pertussis toxin-catalyzed ADP-ribosylation of a 40-kDa protein was significantly attenuated by pretreatment of PGF2α. These results suggest that pertussis toxin-sensitive GTP-binding protein is involved in the coupling of PGF2αreceptor to phospholipase C in these cells.
DOI: --
发表时间: 1985
期刊: The Journal of biological chemistry
影响因子: --
作者:
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通讯作者: Snyderman,R
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DOI: --
发表时间: 1990
期刊: The Journal of biological chemistry
影响因子: --
作者:
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通讯作者: Teitelbaum,I
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发表时间: 1988-02
期刊: The Journal of biological chemistry
影响因子: --
作者:
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影响因子: --
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通讯作者: P. Sternweis;J. Robishaw