Regional analysis of segmented-macular structure in patients with myopic anisometropia
Regional analysis of segmented-macular structure in patients with myopic anisometropia
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DOI：
10.1007/s10792-021-01934-7
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发表时间：
2021-06-29
影响因子：
1.6
通讯作者：
Ozdemir, Hakan
中科院分区：
文献类型：
--
作者：
Kirik, Furkan;Ekinci, Cansu;Ozdemir, Hakan
目的比较近视眼屈光参差患者的眼间视网膜层数，探讨角膜层数与眼轴长度（AL）的关系。方法回顾性分析41例近视眼（MM）和非近视眼(F)和38例远视眼（+/- 0.50屈光度）对照眼(C)。采用光学相干层析进行视网膜内层分割。比较了9个黄斑区视网膜层的整体体积和厚度。采用相关分析确定各层与SE、AL的关系。结果MM眼的视网膜、神经节细胞（GCL）、内核细胞（INL）、外丛状细胞（OPL）总体积小于C眼，而INL和OPL均小于F眼。除视网膜色素上皮外，中央凹无差异。MM眼与F眼相比，只有内视层和外视层在至少一个凹周象限和凹旁象限变薄。只有INL和OPL厚度与SE和AL在所有卵泡周围象限均显著相关。与MM眼相比，与C眼相比，唯一增厚的层是神经纤维层（NFL），其与SE呈正相关，与AL负相关。结论虽然中心凹受近视影响较小，但在中心凹周围象限变薄明显。尽管许多层变薄，特别是INL和OPL，但由于近视，NFL可能会变厚。
Purpose To compare intraretinal layers between the eyes in patients with myopic anisometropia, and evaluate the relationship between the layers with spherical equivalent (SE) and axial length (AL). Methods In this retrospective study, the more myopic (MM) and fellow (F) eyes of 41 patients with myopic anisometropia, and 38 emmetropic (+/- 0.50 diopter) control (C) eyes were inclueded. Intraretinal layer segmentation was performed by optical coherence tomography. Global volumes of retinal layers and their thicknesses in nine macular regions were compared. Correlation analysis was used to determine the relationship with SE and AL in each layer. Results Total retinal, ganglion cell (GCL), inner nuclear (INL), and outer plexiform (OPL) layer volumes in MM eyes were less than in C eyes, while INL and OPL were less than in F eyes. There was no difference in the fovea, except for the retinal pigment epithelium. In MM eyes, only INL and OPL were thin in at least one perifoveal and parafoveal quadrant compared to F eyes. Only INL and OPL thicknesses were significantly correlated with both SE and AL in all perifoveal quadrants. In contrast to the thinning found in MM eyes, the only layer in which thickening was detected to compare to C eye was nerve fiber layer (NFL), which correlated positively with SE and negatively with AL. Conclusion While the fovea is less affected by myopia, thinning becomes remarkable in the perifoveal quadrants. Despite thinning in many layers, especially INL and OPL, NFL thickening may be seen due to myopia.