Hydroxypropyl-modified potato starch increases fecal bile acid excretion in rats
Hydroxypropyl-modified potato starch increases fecal bile acid excretion in rats
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DOI：
10.1093/jn/128.5.848
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发表时间：
1998-05-01
影响因子：
4.2
通讯作者：
Okuma, K
中科院分区：
文献类型：
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作者：
Ebihara, K;Shiraishi, R;Okuma, K
实验一研究了3种不同取代度的羟丙基马铃薯淀粉（HPS）对大鼠血浆胆固醇浓度、蛋白质表观消化率、粪便胆汁酸排泄量、粪便排出量和盲肠有机酸（乙酸、丙酸、丁酸、乳酸和琥珀酸）的影响。试验二研究了三种不同交联度的羟丙基二淀粉磷酸酯（HDP）对相同指标的影响。未进行化学改性（PS）的糊化马铃薯淀粉用作对照。以含HPS、HDP或PS（100 g/kg）的无纤维纯化饲料喂养大鼠21 d。在每个实验中，与饲喂PS饲料的对照大鼠相比，饲喂DS较高的HPS饲料和HDP饲料的大鼠的粪便排出量更大，粪便胆汁酸排泄量更高。饲喂高DS的HPS饲料和高DC的HDP饲料的大鼠的蛋白质表观消化率低于饲喂PS饲料的对照大鼠。盲肠有机酸池的大小不受饮食的影响。试验1中，蛋白质表观消化率、粪排出量和粪胆汁酸排泄量与DS呈显著正相关（r =-0.994，P = 0.0059; r = 0.976，P = 0.0236; r = 0.899，P = 0.0077）。喂食HPS饲料的大鼠血浆胆固醇浓度显著低于喂食PS饲料的对照大鼠。HPS饮食导致较高比例的丙酸，乳酸和琥珀酸和较低比例的正丁酸比PS饮食。试验2中，蛋白质表观消化率与DSP呈显著正相关（r = 0.996，P = 0.0028），与DC呈负相关。HDP饮食不影响血浆胆固醇浓度。HDP饮食导致较高比例的乙酸，乳酸和琥珀酸和较低比例的正丁酸比PS饮食。这些结果表明，化学改性淀粉的生理效应受到改性类型的影响。
The effects of hydroxypropyl potato starches (HPS) of three different degrees of substitution (DS) on concentration of plasma cholesterol, apparent digestibility of protein, fecal excretion of bile acids, fecal output and cecal pool of organic acids such as acetic, propionic, butyric, lactic and succinic acid were studied in rats in Experiment 1. In Experiment 2, the effects of hydroxypropyl distarch phosphate (HDP) of three different degrees of cross-linking (DC) on the same indexes were studied. Gelatinized potato starch that was not modified chemically (PS) was used as a control. Rats were fed a fiber-free, purified diet containing either HPS, HDP or PS (100 g/kg) for 21 d. In each experiment, fecal output was greater and fecal excretion of bile acids was higher in rats fed the HPS diets with higher DS and the HDP diets compared with control rats fed the PS diet. Apparent protein digestibility in rats fed the HPS diets with higher DS and the HDP diets with higher DC was lower than that in control rats fed the PS diet. The pool size of cecal organic acids was not affected by diet. In Experiment 1, apparent protein digestibility, fecal output and fecal bile acids excretion were significantly correlated with DS (r = -0.994, P = 0.0059; r = 0.976, P = 0.0236; and r = 0.899, P = 0.0077, respectively). The plasma cholesterol concentration was significantly lower in rats fed the HPS diets than in control rats fed the PS diet. The HPS diets resulted in higher proportions of propionic acid, lactic acid and succinic acid and a lower proportion of n-butyric acid than the PS diet. In Experiment 2, apparent protein digestibility was significantly correlated with DSP (r = 0.996, P = 0.0028), which was inversely related to DC. The HDP diets did not affect the plasma cholesterol concentration. The HDP diets resulted in higher proportions of acetic acid, lactic acid and succinic acid and a lower proportion of n-butyric acid than the PS diet. These results suggest that the physiological effects of chemically modified starches are affected by the type of modification.