METHODOLOGY FOR THE CONTROL OF INTRA-CRANICAL PRESSURE WITH HYPERTONIC MANNITOL
METHODOLOGY FOR THE CONTROL OF INTRA-CRANICAL PRESSURE WITH HYPERTONIC MANNITOL
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DOI：
10.1007/bf01406742
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发表时间：
1980-01-01
影响因子：
2.4
通讯作者：
JAMES, HE
中科院分区：
文献类型：
--
作者：
JAMES, HE
The response to i.v. bolus administrations and continuous infusions of hypertonic mannitol to control elevated (> 25 torr) intracranial pressure (ICP), is presented. Patients (60) received 120 bolus infusions of mannitol (0.18-2.5 g/kg/dose) with a prompt peak reduction at 44 min (range 18-120 min). There was no relationship between dosage and rapidity of peak response. All administrations of 1.0 g/kg per dose, or higher, consistently reduced ICP 10% or more from control values, but dosages below 1 g/kg per dose did not always reduce ICP. Return to control ICP following mannitol was unpredictable and was related to the initial ICP and the volume of fluid replacement. A continuous infusion of mannitol was administered to maintain ICP below 25 torr in 18 patients. This infusion ranged 6-100 h (.times. 28.8 .+-. 28.9 h) and required a total dosage of 2-20 mg/kg, and was successful in 16 of 18 patients. Emphasis is placed on close observation of the patient''s serum osmolality and electrolytes during therapy, and quality and magnitude of replacement. No set rules are given for control of ICP, but a guideline is made to meet the individual patient''s requirements.
