Revisiting the methionine salvage pathway and its paralogues.
Revisiting the methionine salvage pathway and its paralogues.
复制标题
DOI：
10.1111/1751-7915.13324
复制
发表时间：
2019-01
影响因子：
5.7
通讯作者：
Danchin A
中科院分区：
文献类型：
--
作者：
Sekowska A;Ashida H;Danchin A
蛋氨酸是生命所必需的。它的化学性质使它在氧气的存在下变得脆弱。需氧生物选择了一种回收途径（MSP），该途径利用双氧再生蛋氨酸，并通过棘轮样步骤防止蛋氨酸的反降解。在这里，我们描述了这个主题的变化，在生命之树上发展。氧气在地球上生命出现很久之后才出现。典型的MSP从使用二磷酸核酮糖羧化酶加氧酶（RuBisCO）和甲硫醇作为中间步骤的祖先进化而来。我们记录了这些可能的混杂途径如何被用于代谢无处不在的S -腺苷甲硫氨酸自由基酶的副产物以及醌电子受体的芳香和异戊二烯骨架。
Methionine is essential for life. Its chemistry makes it fragile in the presence of oxygen. Aerobic living organisms have selected a salvage pathway (the MSP) that uses dioxygen to regenerate methionine, associated to a ratchet‐like step that prevents methionine back degradation. Here, we describe the variation on this theme, developed across the tree of life. Oxygen appeared long after life had developed on Earth. The canonical MSP evolved from ancestors that used both predecessors of ribulose bisphosphate carboxylase oxygenase (RuBisCO) and methanethiol in intermediate steps. We document how these likely promiscuous pathways were also used to metabolize the omnipresent by‐products of S‐adenosylmethionine radical enzymes as well as the aromatic and isoprene skeleton of quinone electron acceptors.
登录
查看更多内容
影响因子：
4.5
作者：
Salim HM;Negritto MC;Cavalcanti AR
通讯作者：
Cavalcanti AR
影响因子：
4.1
作者：
BILLINGTON, DC;GOLDING, BT;PRIMROSE, SB
通讯作者：
PRIMROSE, SB
影响因子：
4.4
作者：
Almendros, Marcos;Berenguer, Jose;Sinisterra, Jose-Vicente
通讯作者：
Sinisterra, Jose-Vicente
影响因子：
16.6
作者：
Beaudoin GAW;Li Q;Folz J;Fiehn O;Goodsell JL;Angerhofer A;Bruner SD;Hanson AD
通讯作者：
Hanson AD
影响因子：
14.8
作者：
Bastard, Karine;Perret, Alain;de Berardinis, Veronique
通讯作者：
de Berardinis, Veronique