Fasting and Nonfasting Lipid Levels Influence of Normal Food Intake on Lipids, Lipoproteins, Apolipoproteins, and Cardiovascular Risk Prediction
Fasting and Nonfasting Lipid Levels Influence of Normal Food Intake on Lipids, Lipoproteins, Apolipoproteins, and Cardiovascular Risk Prediction
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DOI：
10.1161/circulationaha.108.804146
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发表时间：
2008-11-11
期刊：
影响因子：
37.8
通讯作者：
Nordestgaard, Borge G.
中科院分区：
文献类型：
--
作者：
Langsted, Anne;Freiberg, Jacob J.;Nordestgaard, Borge G.
背景--通常在禁食后测量血脂水平。我们测试了这些水平只对正常食物摄入量有微小影响的假设，以及非禁食水平预测心血管事件的假设。方法和结果-我们横断面研究了哥本哈根普通人口研究中年龄在20岁到95岁之间的33391人。我们还研究了哥本哈根城市心脏研究中9319名年龄在20岁至93岁之间的人，其中1166人在14年的随访中发生了心血管事件。与空腹水平相比，总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和白蛋白水平在最后一餐后3~5小时降低，甘油三酯水平在最后一餐后6小时升高，非高密度脂蛋白胆固醇水平、载脂蛋白A1水平、载脂蛋白B水平、总胆固醇/高密度脂蛋白胆固醇水平、载脂蛋白B/载脂蛋白A1比率没有因正常食物摄入量而改变。正常摄入食物和水后空腹水平的最大变化为：总胆固醇-0.2mmoL/L，低密度脂蛋白胆固醇-0.2mmoL/L，高密度脂蛋白胆固醇-0.1mmoL/L，甘油三酯0.3mmoL/L。非空腹总胆固醇、非高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白B、甘油三酯、总胆固醇/高密度脂蛋白、载脂蛋白B/载脂蛋白A1的最高与最低三分位数以及非空腹高密度脂蛋白胆固醇和载脂蛋白A1的最低与最低三分位数预测心血管事件的风险增加1.7-2.4倍。此外，非空腹血脂谱预测心血管事件的风险增加。(发行量。2008；118：2047-2056。)
Background - Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events.Methods and Results - We cross-sectionally studied 33 391 individuals 20 to 95 years of age from the Copenhagen General Population Study. We also studied 9319 individuals 20 to 93 years of age from the Copenhagen City Heart Study, 1166 of whom developed cardiovascular events during 14 years of follow-up. Compared with fasting levels, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, and albumin levels were reduced up to 3 to 5 hours after the last meal; triglycerides levels were increased up to 6 hours after the last meal; and non-HDL cholesterol level, apolipoprotein A1 level, apolipoprotein B level, ratio of total cholesterol to HDL cholesterol, and ratio of apolipoprotein B to apolipoprotein A1 did not change in response to normal food intake. The maximum changes after normal food and fluid intake from fasting levels were -0.2 mmol/L for total cholesterol, -0.2 mmol/L for low-density lipoprotein cholesterol, -0.1 mmol/L for HDL cholesterol, and 0.3 mmol/L for triglycerides. Highest versus lowest tertile of nonfasting total cholesterol, non-HDL cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, triglycerides, ratio of total cholesterol to HDL cholesterol, and ratio of apolipoprotein B/apolipoprotein A1 and lowest versus highest tertile of nonfasting HDL cholesterol and apolipoprotein A1 predicted 1.7- to 2.4-fold increased risk of cardiovascular events.Conclusions - Lipid profiles at most change minimally in response to normal food intake in individuals in the general population. Furthermore, nonfasting lipid profiles predicted increased risk of cardiovascular events. (Circulation. 2008; 118: 2047-2056.)