Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment
Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment
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DOI：
10.1111/j.1465-3362.2012.00423.x
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发表时间：
2013-01-01
影响因子：
3.8
通讯作者：
Shoptaw, Steven J.
中科院分区：
文献类型：
--
作者：
Brensilver, Matthew;Heinzerling, Keith G.;Shoptaw, Steven J.
介绍和目标。吸烟经常发生在甲基苯丙胺（MA）依赖的个体中。临床前和临床证据表明，MA和香烟的共同滥用是一种非常有意义的模式。方法.本研究是安非他酮治疗MA依赖的随机、安慰剂对照试验的次要分析（安非他酮n = 36;安慰剂n = 37）。分层逻辑建模方法评估了安非他酮分别在吸烟者和非吸烟者中减少MA使用的有效性。在吸烟者中，评估了吸烟与MA使用之间的关系。结果吸烟状态不影响安非他酮条件或安慰剂条件下的治疗反应。在安慰剂条件下，增加吸烟与同一时期MA使用概率增加相关。在安非他酮条件下未观察到这种效应。讨论和结论。最初的吸烟状态不影响治疗结果。在吸烟者中，结果表明，安非他酮可能分离香烟和MA的使用。其作用不大，精确的药理机制仍然难以捉摸。胆碱能系统可能与MA使用结局相关。未来的研究应继续评估吸烟在MA治疗结局中的作用。[Brensilver M，Heinzerling KG，Swanson A-N，Telesca D，Furst BA，Shoptaw SJ.吸烟作为甲基苯丙胺滥用治疗的靶点。药物酒精Rev 2013;32：9699]
Introduction and Aims. Cigarette smoking occurs frequently among individuals with methamphetamine (MA) dependence. Preclinical and clinical evidence has suggested that the common co-abuse of MA and cigarettes represents a pharmacologically meaningful pattern. Methods. The present study is a secondary analysis of a randomised, placebo-controlled trial of bupropion treatment for MA dependence (bupropion n = 36; placebo n = 37). A hierarchical logistic modelling approach assessed the efficacy of bupropion for reducing MA use separately among smokers and non-smokers. Among smokers, relations between cigarettes smoked and MA use were assessed. Results. Smoking status did not affect treatment responsiveness in either the bupropion condition or the placebo condition. In the placebo condition, increased cigarette use was associated with an increased probability of MA use during the same time period. This effect was not observed in the bupropion condition. Discussion and Conclusions. Initial smoking status did not impact treatment outcomes. Among smokers, results suggest that bupropion may dissociate cigarette and MA use. The effect was modest and a precise pharmacological mechanism remains elusive. Cholinergic systems may be relevant for MA use outcomes. Future studies should continue to assess the role of smoking in MA treatment outcomes.[Brensilver M, Heinzerling KG, Swanson A-N, Telesca D, Furst BA, Shoptaw SJ. Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment. Drug Alcohol Rev 2013;32:9699]