Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.
Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.
复制标题
DOI：
--
复制
发表时间：
1990-08
期刊：
影响因子：
4.6
通讯作者：
R. Klein;D. Martín-Zanca;M. Barbacid;L. Parada
中科院分区：
文献类型：
--
作者：
R. Klein;D. Martín-Zanca;M. Barbacid;L. Parada
我们用原位杂交和Northern分析检测了编码蛋白酪氨酸激酶(TK)跨膜受体家族成员的TrkB基因在小鼠胚胎发育过程中的表达。在9.5d胚胎的神经上皮和神经脊中首次检测到转录本，在神经皱折和外侧神经上皮中高表达的区域。然而，在外周神经系统的头化和发育过程中，在包括脑、脊髓、颅神经节和脊神经节在内的大多数神经组织中都检测到了转录本，并沿着轴索向外延伸的路径进行了检测。在成人大脑中，表达继续以复杂的模式进行，仅限于特定的区域或神经元类型。TrkB是一种TK受体，在早期胚胎发育中的表达，特别是在神经组织中的表达，与该基因在调节神经系统发育的事件中发挥作用的概念是一致的。
We have examined the expression of the trkB gene, which encodes a member of the family of protein tyrosine kinase (TK) transmembrane receptors, during mouse embryogenesis using in situ hybridization and Northern analysis. Transcripts were first detected in the neuroepithelium and in the neural crest of 9.5 day embryos with regions of high expression in the neural folds and at the lateral neuroepithelium. However, during the process of cephalization and development of the peripheral nervous system, transcripts were detected in most neural tissues, including the brain, spinal cord, cranial and spinal ganglia, and along the pathways of axonal tracts extending peripherally. In the adult brain, expression continues in a complex pattern that is confined to specific regions or neuron types. The expression of trkB, a TK receptor, in early embryogenesis, and specifically in neural tissues, is consistent with the notion that this gene plays a role in the events that regulate the development of the nervous system.