Electrical stimulation of the human claustrum
Electrical stimulation of the human claustrum
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DOI：
10.1016/j.yebeh.2019.03.051
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发表时间：
2019-08-01
影响因子：
2.6
通讯作者：
Parvizi, Josef
中科院分区：
文献类型：
--
作者：
Bickel, Stephan;Parvizi, Josef
为了探讨屏状体在人类主观体验中的因果重要性，我们在5例植入颅内电极的神经外科患者中，在该结构的核心内单侧或双侧传递电脉冲。患者报告了不同感觉领域的主观体验，并在真实而非虚假刺激后表现出反射运动。然而，即使有强烈的双侧刺激，也没有任何刺激引起意识丧失或缺乏主观意识。我们的研究首次通过植入屏状体内部的电极来探索电扰动对人类屏状体的影响，并提供了关于人类屏状体的新的因果信息。(C) 2019 Elsevier Inc.版权所有。
To probe the causal importance of the claustrum in human subjective experience, we delivered electrical pulses either unilaterally or bilaterally within the core of this structure in five neurosurgical patients implanted with intracranial electrodes. Patients reported subjective experiences in various sensory domains and exhibited reflexive movements after real but not sham stimulations. However, none of the stimulations evoked loss of consciousness or lack of subjective awareness even with strong bilateral stimulations. Our study is the first to probe the effects of electrical perturbation of human claustrum through electrodes implanted within the claustrum itself and provide novel causal information about the human claustrum. (C) 2019 Elsevier Inc. All rights reserved.