EPILEPTOGENIC EFFECT OF HYPOXIA IN THE IMMATURE RODENT BRAIN
EPILEPTOGENIC EFFECT OF HYPOXIA IN THE IMMATURE RODENT BRAIN
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DOI：
10.1002/ana.410290610
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发表时间：
1991-06-01
影响因子：
11.2
通讯作者：
BURCHFIEL, JL
中科院分区：
文献类型：
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作者：
JENSEN, FE;APPLEGATE, CD;BURCHFIEL, JL
与其他年龄组相比，新生儿对脑缺氧/缺血的反应可能不同。 在大鼠体内模型的开发，以确定是否有年龄依赖性的差异，缺氧对脑电图（EEG）活动的影响。 EEG记录从Long Evans hooded大鼠缺氧，在五个年龄：出生后第5至7天，10至12，15至17，25至27，50至60。 动物之间的氧浓度在0、2、3和4%之间变化。 在暴露于低氧条件之前、期间和之后1小时以及之后1至7天在动物亚组中记录所有动物的EEG。 所有动物均缺氧，直至呼吸暂停和心动过缓发作至基线心率值的20 - 40%。 缺氧导致等电位脑电图显着更频繁的动物在出生后第25至27天和50至60天缺氧比年轻的年龄组。 一个非常显着的影响是，动物剥夺出生后5至17天，发现癫痫样脑电图活动在缺氧的高发病率。 相比之下，年长的动物在达到等电位EEG之前仅表现出罕见的孤立EEG尖峰。 缺氧诱导的癫痫样脑电图变化的严重程度是最高的动物进行中度缺氧条件（3%和4%的氧气）在出生后第10至12天。 此外，癫痫样变化持续数小时至数天后，长期缺氧的年轻动物。 这项研究证明了一个独特的反应，未成熟的大脑表现出癫痫样活动在缺氧。
The response to cerebral hypoxia/ischemia may be different in the neonate compared to other age groups. An in vivo model was developed in the rat to determine whether there are age-dependent differences in the effects of hypoxia on electroencephalographic (EEG) activity. EEG recordings were obtained from Long Evans hooded rats deprived of oxygen at five ages: postnatal days 5 to 7, 10 to 12, 15 to 17, 25 to 27, and 50 to 60. Oxygen concentration was varied from 0, 2, 3, and 4% between animals. EEGs were recorded in all animals before, during, and at 1 hour after exposure to the hypoxic condition and at 1 to 7 days afterward in a subset of animals. All animals were deprived of oxygen until the onset of apnea and bradycardia to 20 to 40% of baseline heart rate values. Hypoxia resulted in isoelectric EEG significantly more frequently in the animals deprived of oxygen at postnatal days 25 to 27 and 50 to 60 than in the younger age groups. A highly significant effect was that the animals deprived at postnatal days 5 to 17 revealed a high incidence of epileptiform EEG activity during hypoxia. In contrast, the older animals exhibited only rare isolated EEG spikes before reaching an isoelectric EEG. The severity of hypoxia-induced epileptiform EEG changes was highest in the animals subjected to moderately hypoxic conditions (3% and 4% oxygen) at postnatal days 10 to 12. Furthermore, epileptiform changes persisted for hours to days following prolonged episodes of hypoxia in the younger animals. This study demonstrates a unique response of the immature brain to exhibit epileptiform activity during hypoxia.