Adjunctive effect of orthokeratology and low dose atropine on axial elongation in fast-progressing myopic children-A preliminary retrospective study
Adjunctive effect of orthokeratology and low dose atropine on axial elongation in fast-progressing myopic children-A preliminary retrospective study
复制标题
角膜塑形镜和小剂量阿托品对快速进展性近视儿童眼轴延长的辅助作用——初步回顾性研究
DOI：
10.1016/j.clae.2018.10.026
复制
发表时间：
2019-08-01
影响因子：
3.2
通讯作者：
Xue, Feng
中科院分区：
文献类型：
--
作者：
Chen, Zhi;Huang, Shengmei;Xue, Feng
目的：研究正差异学（Ortho-K）和低剂量阿托品眼睛的辅助作用对快速培养的近视儿童的轴向长度伸长。回顾性地审查了治疗。他们在开始Ortho-K治疗时年龄在5.6-11.6（平均值为8.3 +/- 1.5）之间。在Ortho-K治疗的第一年（第一阶段）中，它们的表现都比0.25 mm/yr轴向伸长率快。然后，除了再治疗Ortho-K治疗，还将用每晚0.01％的阿托品治疗（第二阶段）。比较阿托品处理前后的年度轴向伸长率。结果：研究队列的基线球形等效折射率为-2.65 +/- 1.08 DS，轴向长度为24.34 +/- 0.92 mm。在第一阶段的平均轴向伸长率为0.46 +/- 0.16 mm/yr，在幼儿中的速度明显更快（t = -4.920，p <0.001）。当添加阿托品时，年度轴向伸长率显着降低至0.14 +/- 0.14 mm/yr（t = -11.988，p <0.001），那些在第一阶段中快速流行者的人的轴向延伸速率较大降低在第二阶段（t = -8.052，p <0.001）中。结论：接受Ortho-K治疗的年幼儿童的轴向伸长率更快。对于快速的近视进度者，除了Ortho-K的治疗效果外，低剂量的阿托品可能会显着降低轴向伸长。那些在Ortho-K处理后具有更快的轴向伸长率的人将从添加低剂量阿托品的添加中受益，而不管其折射率和年龄如何。
Purpose: To investigate the adjunctive effect of orthokeratology (ortho-k) and low-dose atropine eye drops on axial length elongation in fast-progressing myopic children.Methods: Axial elongation in 60 eyes of 60 subjects who completed two years of ortho-k treatment was retrospectively reviewed. They were aged between 5.6-11.6 (mean, 8.3 +/- 1.5) years old when they started ortho-k treatment. During their first year of ortho-k treatment (Phase One), they all demonstrated a faster than 0.25 mm/yr axial elongation rate. They were then treated with nightly 0.01% atropine in addition to ortho-k treatment for another year (Phase Two). Annual axial elongation rates before and after atropine treatment were compared.Results: Baseline spherical equivalent refractive error was -2.65 +/- 1.08 DS and axial length was 24.34 +/- 0.92 mm for the study cohort. The mean axial elongation rate was 0.46 +/- 0.16 mm/yr during Phase One, being significantly faster in younger children (t = -4.920, P < 0.001). When atropine was added, annual axial elongation rate significantly decreased to 0.14 +/- 0.14 mm/yr (t=-11.988, P < 0.001), and those who were fast progressors in Phase One had a greater reduction in the rate of axial elongation during Phase Two (t=-8.052, P < 0.001).Conclusions: Axial elongation rate is faster in younger children undergoing ortho-k treatment. For fast myopia progressors, low dose atropine may significantly slow axial elongation in addition to ortho-k's treatment effect. Those who have faster axial elongation after ortho-k treatment will benefit more from the addition of low dose atropine, regardless of their refractive error and age.