Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives
Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives
复制标题
金催化分子间[4 1]螺环化通过位点选择性芳族C(sp(2))-H官能化和苯酚衍生物的脱芳构化
DOI：
10.1039/d0cc01118e
复制
发表时间：
2020-07-28
影响因子：
4.9
通讯作者：
Liu, Lu
中科院分区：
文献类型：
--
作者：
Li, Yongfeng;Tang, Zhiqiong;Liu, Lu
本文发展了一种新的、简单的金催化邻炔芳基-α-重氮酯对萘酚和苯酚的C-H键官能化/脱芳构化反应。在该方案中，可以以良好的产率获得各种螺环分子，具有优异的化学选择性和区域选择性以及中等至良好的非对映选择性。
Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols withortho-alkynylaryl-alpha-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.