Prostacyclin and thromboxanes. Implications for their role in tumor cell metastasis.
Prostacyclin and thromboxanes. Implications for their role in tumor cell metastasis.
复制标题
前列环素和血栓素。
DOI：
10.1016/0006-2952(83)90644-5
复制
发表时间：
1983
影响因子：
5.8
通讯作者：
Sloane,BF
中科院分区：
文献类型：
--
作者：
Honn,KV;Busse,WD;Sloane,BF
栓塞内肿瘤细胞的血管屏蔽和肿瘤血小板栓塞抑制微血管的能力增加，可能阻塞毛细前括约肌。这将导致远端缺氧和瘀滞，并可能损害内皮（微损伤假说）。其他可能的机制是：肿瘤细胞通过血小板桥更强地粘附到内皮下基质，保护附着的肿瘤细胞免受循环系统剪切力的影响，以及血小板衍生生长因子的释放提高了肿瘤细胞的存活率。上述每种提示的机制与血小板增强肿瘤细胞转移的相关性仍有待确定。
ical shielding of tumor cells within the emboli and increased ability of tumor platelet emboli to arrest in the microvasculature with possible occlusion of a precapillary sphincter. This would result in distal hypoxia and stasis with possible damage to the endothelium (microinjury hypothesis). Additional possible mechanisms are: greater adhesion of tumor cells to the subendothelial matrix via platelet bridges, protection of attached tumor cells from shear forces in the circulatory system, and enhanced tumor cell survival due to the release of platelet derived growth factors. The relevance of each of the above-suggested mechanisms to platelet enhancement of tumor cell metastasis remains to be established.