Adult height, age at attained height, and incidence of breast cancer in premenopausal women
Adult height, age at attained height, and incidence of breast cancer in premenopausal women
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DOI：
10.1002/ijc.22096
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发表时间：
2006-11-01
影响因子：
6.4
通讯作者：
Michels, Karin B.
中科院分区：
文献类型：
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作者：
Baer, Heather J.;Rich-Edwards, Janet W.;Michels, Karin B.
在流行病学研究中，成人身高与乳腺癌风险呈正相关，最近的证据表明，生长的时间和速度也可能影响风险。在《护士健康研究II》中，我们研究了成人身高和身高年龄(青春期生长时间的一个指标)与绝经前乳腺癌发病率的关系。参与者是108,829名绝经前女性，她们在1989年报告了身高；其中37,572人在后来的补充问卷中提供了她们达到身高时的年龄信息。在12年的随访中，发现了1041例浸润性乳腺癌(402例年龄达到一定高度)。用Cox比例风险模型估计相对危险度(RR)和95%可信区间(CI)。成人身高与乳腺癌发病率呈正相关；身高1.75m或更高的人与身高小于1.60m的人相比，多变量RR为1.57(95%CI：1.23-2.01，p趋势和t；0.0001)，每增加5厘米对应的风险增加11%(95%CI：6-17%)。然而，与14岁之前达到最大身高的女性相比，18岁或更大年龄达到最大身高的女性的多变量RR为0.96(95%可信区间：0.66-1.39)，但没有总体上的相关性。这些结果证实了先前的发现，即成人身高较高与绝经前乳腺癌风险增加有关，但并未提供证据表明达到身高时的年龄与风险相关。(C)2006年Wiley-Liss，Inc.
Adult height has been positively associated with breast cancer risk in epidemiologic studies, and recent evidence suggests that the timing and rate of growth may also influence risk. We examined both adult height and age at attained height, an indicator of the timing of the pubertal growth spurt, in relation to incidence of premenopausal breast cancer in the Nurses' Health Study II. Participants were 108,829 premenopausal women who reported their height in 1989; of these, 37,572 provided information on their age at attained height on a later supplementary questionnaire. During 12 years of follow-up, 1,041 cases of invasive breast cancer were identified (402 with age at attained height). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs). Adult height was positively associated with breast cancer incidence; the multivariate RR for participants 1.75 m or taller compared to those shorter than 1.60 m was 1.57 (95% CI: 1.23-2.01, p trend < 0.0001), and each 5-cm increment corresponded to an 11% increase in risk (95% CI: 6-17%). There was no overall association for age at attained height, however, with a multivariate RR of 0.96 (95% CI: 0.66-1.39) for women who attained their maximum height at age 18 or older compared to those who reached it before age 14 (p trend = 0.65). These results confirm previous findings that taller adult height is associated with increased risk of premenopausal breast cancer but do not provide evidence that age at attained height is related to risk. (c) 2006 Wiley-Liss, Inc.