NEURONAL DISCHARGE OF PREOPTIC-ANTERIOR HYPOTHALAMIC THERMOSENSITIVE NEURONS - RELATION TO NREM SLEEP
NEURONAL DISCHARGE OF PREOPTIC-ANTERIOR HYPOTHALAMIC THERMOSENSITIVE NEURONS - RELATION TO NREM SLEEP
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DOI：
10.1152/ajpregu.1995.269.5.r1240
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发表时间：
1995-11-01
影响因子：
2.8
通讯作者：
SZYMUSIAK, R
中科院分区：
文献类型：
--
作者：
ALAM, MN;MCGINTY, D;SZYMUSIAK, R
原丘脑前/前下丘脑区域（POAH）的热敏神经元已与非比比眼运动（NREM）睡眠的调节有关。我们试图识别可能涉及NREM睡眠调节的那些内侧POAH热敏神经元。通过局部冷却或用水灌注的热极将局部冷却或变暖，对五只自由移动的成年猫进行了内侧POAH神经元的热敏性。在308个神经元中，有65个（21％）被归类为热敏感，包括31（10％）温敏感和34（11％）冷敏感神经元。通过一到三个饮用的循环记录了28个热敏感，34个冷敏感和115个随机选择的热敏感神经元的自发放电速率。温暖和冷敏感性神经元的自发活性模式不同。与醒来相比，在28个热敏神经元中，在NREM睡眠期间的出院率提高（NREM/Wake，大于或等于1.2）。在NREM睡眠期间测试时，温敏神经元的这种亚群也显着增加了热敏性。在NREM睡眠期间，在34个冷敏感性神经元中，与醒来（NREM/Wake，小于或等于0.8）相比，25（74％）的排出速度较慢。冷敏神经元的这种亚群显示在NREM睡眠期间表现出降低的热敏性。这些结果与一个假设是一致的，即与睡眠相关的温敏神经元的激活以及与唤醒相关的冷敏感性神经元失活可能在NREM睡眠的发作和调节中起关键作用。
Thermosensitive neurons of the preoptic/anterior hypothalamic area (POAH) have been implicated in the regulation of non-rapid eye movement(NREM) sleep. We attempted to identify those medial POAH thermosensitive neurons that may be involved in NREM sleep regulation. The thermosensitivity of medial POAH neurons was studied in five freely moving adult cats by local cooling or warming of the medial POAH with a water-perfused thermode. Of 308 neurons, 65 (21%) were classified as thermosensitive, including 31 (10%) warm-sensitive and 34 (11%) cold-sensitive neurons. The spontaneous discharge rates of 28 warm-sensitive, 34 cold-sensitive, and 115 randomly selected thermoinsensitive neurons were recorded through one to three sleep-waking cycles. Patterns of spontaneous activity for warm- and cold-sensitive neurons were different. Of 28 warm-sensitive neurons, 18 (64%) exhibited increased discharge rate during NREM sleep compared with waking (NREM/wake, greater than or equal to 1.2). This subpopulation of warm-sensitive neurons also exhibited significantly increased thermosensitivity when tested during NREM sleep. Of 34 cold-sensitive neurons, 25 (74%) discharged more slowly during NREM sleep compared with waking (NREM/wake, less than or equal to 0.8). This subpopulation of cold-sensitive neurons exhibited decreased thermosensitivity during NREM sleep. These results are consistent with a hypothesis that the activation of sleep-related warm-sensitive neurons and the deactivation of wake-related cold-sensitive neurons may play a key role in the onset and regulation of NREM sleep.