Epstein-Barr virus antibodies in children with atopic disease.
Epstein-Barr virus antibodies in children with atopic disease.
复制标题
患有特应性疾病的儿童中的 Epstein-Barr 病毒抗体。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
O. Strannegard
中科院分区：
文献类型：
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作者：
I. Strannegård;O. Strannegard
在98名特应性疾病儿童和55名非特应性对照儿童中测定了人类疱疹病毒以及风疹和腮腺炎病毒抗体的流行率和滴度。两组之间唯一的显著差异是EB病毒（EBV）抗体，在所有年龄段的特应性儿童中发现了更高的滴度。在哮喘和特应性皮炎儿童中发现EBV抗体水平升高。在所有年龄组中，特应性变态反应患者的EBV血清阳性率略高于对照组，但观察到的差异无统计学意义。EB病毒是一种B细胞有丝分裂原，在IgE的过度产生和特应性疾病的发展中具有致病作用，这一可能性应予以考虑。
The prevalence and titers of antibodies to human herpetoviruses as well as rubella and mumps viruses were determined in 98 children with atopic diseases and in 55 nonatopic control children. The only significant difference between the two groups was found as regards Epstein-Barr virus (EBV) antibodies, which were found in higher titers in atopic children of all ages. Increased levels of EBV antibodies were found both in children with asthma and atopic dermatitis. The frequency of seropositivity for EBV was slightly higher in atopics than in controls in all age-groups, but the differences observed were not statistically significant. The possibility that EBV, which is a B-cell mitogen, has a pathogenic role in the hyperproduction of IgE and development of atopic disease, should be considered.