Failure to detect human immunodeficiency virus type 1 superinfection in 28 HIV-seroconcordant individuals with high risk of reexposure to the virus
Failure to detect human immunodeficiency virus type 1 superinfection in 28 HIV-seroconcordant individuals with high risk of reexposure to the virus
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DOI：
10.1089/aid.2004.20.1026
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发表时间：
2004-09-01
影响因子：
1.5
通讯作者：
Quiñones-Mateu, ME
中科院分区：
文献类型：
--
作者：
Chakraborty, B;Valer, L;Quiñones-Mateu, ME
We have examined the occurrence of HIV-1 superinfection in 14 HIV-seroconcordant couples (i.e., partners were independently infected with different HIV-1 strains) with high risk of reexposure to the virus. Phylogenetic analyses based on pol and env global sequences obtained from more than 100 longitudinal plasma samples ( corresponding to a period of 1 - 4 years) failed to detect HIV-1 superinfection in this cohort of patients. Our results suggest that despite recent reports of HIV-1 reinfection, chronic HIV infection seems to confer protection against superinfection with a second HIV-1 strain.
