Gender differences of B cell signature in healthy subjects underlie disparities in incidence and course of SLE related to estrogen.
Gender differences of B cell signature in healthy subjects underlie disparities in incidence and course of SLE related to estrogen.
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DOI：
10.1155/2014/814598
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发表时间：
2014
影响因子：
4.1
通讯作者：
Hou Y
中科院分区：
文献类型：
--
作者：
Fan H;Dong G;Zhao G;Liu F;Yao G;Zhu Y;Hou Y
本研究旨在探讨B细胞性别差异的机制。结果表明，健康女性与男性之间存在358个差异表达基因（DEG）。与男性相比，女性中有226个和132个基因上调和下调。116个基因与雌激素可能相关。此外，在健康女性中上调的DEG（Cav1、CD200R1、TNFRSF17和CXCR3）和下调的DEG（EIF1AY和DDX3Y）可能参与某些免疫疾病的性别优势。雌激素相关DEG信号通路分析显示，女性SLE患者中仅有26个基因表达下调，其中8个基因的表达在男性和女性间差异显著，而在健康男性和女性间差异不显著。除5个Y染色体相关基因或变异体外，仅选择3个DEG（LTF、CAMP和DEFA 4），qRT-PCR证实LTF和CAMP在女性SLE患者的B细胞中的表达显著降低。提示B细胞基因表达存在性别差异，这种差异可能与雌激素有关。
The aim of the present study was to investigate mechanism of the gender differences of B cells. The results showed that 358 differential gene expressions (DEGs) were displayed between healthy females and males. Compared with male, 226 and 132 genes were found to be up- and downregulated in the female. 116 genes displayed possible correlation with estrogen. Moreover, the upregulated DEGs (Cav1, CD200R1, TNFRSF17, and CXCR3) and downregulated DEGs (EIF1AY and DDX3Y) in healthy female may be involved in gender predominance of some immune diseases. Furthermore, signaling pathway analysis for estrogen-relevant DEGs showed that only 26 genes were downregulated in SLE female versus SLE male, of which expressions of 8 genes had significant difference between SLE females and SLE males but are having nonsignificant difference between healthy females and healthy males. Except for the 5 Y-chromosome-related genes or varients, only 3 DEGs (LTF, CAMP, and DEFA4) were selected and qRT-PCR confirmed that the expressions of LTF and CAMP decreased significantly in B cells from female SLE patients. These data indicated that the gender differences were existent in global gene expression of B cells and the difference may be related to estrogen.
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影响因子：
6.5
作者：
Gilling, Christine E.;Mittal, Amit K.;Joshi, Shantaram S.
通讯作者：
Joshi, Shantaram S.
DOI：
10.1152/ajplung.00018.2012
发表时间：
2012-10-01
影响因子：
4.9
作者：
Aravamudan, Bharathi;VanOosten, Sarah K.;Pabelick, Christina M.
通讯作者：
Pabelick, Christina M.
影响因子：
3.7
作者：
Bund, D.;Buhmann, R.;Schmetzer, H. M.
通讯作者：
Schmetzer, H. M.
DOI：
10.1084/jem.20112398
发表时间：
2012-09-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hara-Chikuma M;Chikuma S;Sugiyama Y;Kabashima K;Verkman AS;Inoue S;Miyachi Y
通讯作者：
Miyachi Y
Caveolin-1 参与 Jak-Stat 信号通路和鳜鱼 (Siniperca chuatsi) 感染性脾肾坏死病毒感染。
影响因子：
3.6
作者：
Guo CJ;Yang XB;Wu YY;Yang LS;Mi S;Liu ZY;Jia KT;Huang YX;Weng SP;Yu XQ;He JG
通讯作者：
He JG