Prevalence of hepatitis C virus infection among men who have sex with men at a Boston community health center and its association with markers of high-risk behavior
Prevalence of hepatitis C virus infection among men who have sex with men at a Boston community health center and its association with markers of high-risk behavior
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DOI：
10.1089/apc.2006.20.557
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发表时间：
2006-08-01
影响因子：
4.9
通讯作者：
Mayer, Kenneth H.
中科院分区：
文献类型：
--
作者：
Cohen, Daniel E.;Russell, Christopher J.;Mayer, Kenneth H.
本研究旨在调查在社区卫生中心就诊的男男性行为者（MSM）中丙型肝炎病毒（HCV）的流行情况，并检查与感染相关的危险因素。研究人群包括218名男男性行为者，他们在2001年5月至12月的常规门诊就诊期间接受了丙型肝炎病毒感染筛查。接受筛查的人中有84%（183人）同意完成一份评估药物使用、性行为和病史的自我报告问卷。参与者的年龄从22岁到54岁不等。大多数参与者（82%）自认为是白种人，35%是艾滋病毒阳性。HCV感染率为11.5%。感染丙型肝炎病毒的男性比未感染丙型肝炎病毒的男性更容易同时感染艾滋病毒和乙型肝炎，并且有直肠或尿道淋病史。感染丙型肝炎病毒的男性更有可能在共用的可卡因吸管上看到血，并在过去6个月内使用过快克可卡因。总体而言，12%的丙型肝炎病毒感染男性报告没有丙型肝炎病毒感染的肠外危险因素。HCV血清阳性与过去6个月高危行为的总得分显著相关。丙型肝炎病毒的预防和筛查应针对从事高危性行为的男同性恋者。相反，降低艾滋病毒和性传播感染风险的干预措施应针对感染丙型肝炎病毒的男男性行为者。
The present study sought to investigate the prevalence of hepatitis C virus (HCV) among men who have sex with men (MSM) seen at a community health center, and to examine risk factors associated with infection. The study population included 218 MSM who were screened for HCV infection during routine clinic visits from May through December, 2001. Eighty-four percent of those screened (n = 183) agreed to complete a self-report questionnaire assessing drug use, sexual practices, and medical history. Participants ranged in age from 22 to 54 years. The majority of participants (82%) self-identified as Caucasian and 35% were HIV-positive. Prevalence of HCV infection was 11.5%. Men infected with HCV were more likely than HCV uninfected men to be coinfected with HIV and hepatitis B, and to have a history of rectal or urethral gonorrhea. HCV-infected men were more likely to have seen blood on shared cocaine straws and to have used crack cocaine in the past 6 months. Overall, 12% of HCV-infected men reported no parenteral risk factors for HCV infection. HCV seropositivity was significantly associated with an aggregate score representing high-risk behavior in the past six months. HCV prevention and screening should target MSM engaging in high-risk sex. Conversely, HIV and sexually transmitted infection risk reduction interventions should be targeted at MSM with HCV.