Copper-copper oxide coated nanofibrillar cellulose: a promising biomaterial
Copper-copper oxide coated nanofibrillar cellulose: a promising biomaterial
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DOI：
10.1039/c3ra42209g
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Karak, Niranjan
中科院分区：
文献类型：
--
作者：
Barua, Shaswat;Das, Gautam;Karak, Niranjan
纳米纤维素作为一种分层材料在许多先进的应用中获得了推动力。从容易获得的生物资源中分离纳米纤维素是一个有待深入研究的领域。本文着重介绍了从丰富的天然资源，芋头，通过化学方法分离纳米纤维纤维素。纳米纤维通过使用诃子果实的醇提取物的“绿色”还原技术用铜-氧化铜纳米颗粒涂覆。通过傅立叶变换红外光谱、X射线衍射和透射电子显微镜对所制备的纤维和纳米杂化物进行了表征。包覆后的纳米纤维对金黄色葡萄球菌、大肠杆菌和白色念珠菌具有良好的抗菌活性。该纳米杂交体与外周血单核细胞（PBMC）以及哺乳动物红细胞（RBC）非常相容。牛血清白蛋白（BSA）的结构完整性与纳米杂化物相互作用后不变。这里提出的生物相容性和抗微生物纳米杂化材料具有很高的潜力，可用作现代生物医学领域的合适利基中的生物材料。
Nanocellulose is gaining impetus as a hierarchical material in many advanced applications. The isolation of nanocellulose from easily available bio-resources is an area to be delved into thoroughly. This article highlights the isolation of nanofibrillar cellulose from an abundant natural source, Colocasia esculenta, by a chemical method. The nanofibrils were coated with copper-copper oxide nanoparticles through a 'green' reductive technique using the alcoholic extract of Terminalia chebula fruit. The prepared fibrils and the nanohybrid were characterized by Fourier transformed infrared spectroscopy, X-ray diffraction and transmission electron microscopic studies. The coated nanofibrils showed promising antimicrobial activity against Staphyllococcus aureus, Escherichia coli and Candida albicans. The nanohybrid was quite compatible with peripheral blood mononuclear cells (PBMC) as well as mammalian red blood cells (RBCs). The structural integrity of bovine serum albumin (BSA) was unaltered upon interaction with the nanohybrid. The biocompatible and antimicrobial nanohybrid presented here possesses high potential to be used as a biomaterial in a suitable niche of modern biomedical fields.