Role of Sphingolipid Signaling in Glomerular Diseases: Focus on DKD and FSGS.
Role of Sphingolipid Signaling in Glomerular Diseases: Focus on DKD and FSGS.
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DOI：
10.33696/signaling.1.013
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发表时间：
2020-09-01
期刊：
影响因子：
--
通讯作者：
Fornoni, Alessia
中科院分区：
文献类型：
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作者：
Mitrofanova, Alla;Drexler, Yelena;Fornoni, Alessia
鞘脂类物质被公认为在包括慢性肾病在内的多种人类疾病的发病机制中发挥重要作用。肾脏是一个对鞘脂代谢变化非常敏感的器官。本综述要探讨的关键问题涉及鞘脂类物质以及参与鞘脂代谢的酶在肾小球疾病发病机制中的作用，特别聚焦于足细胞，它是肾小球滤过屏障的关键细胞成分。在众多鞘脂类物质中，我们将着重阐述神经酰胺、鞘氨醇、鞘氨醇 - 1 - 磷酸和神经酰胺 - 1 - 磷酸的作用。此外，我们还将总结目前关于使用鞘脂类物质作为治疗肾病中足细胞损伤的治疗药物的相关知识。
Sphingolipids are well-recognized as major players in the pathogenesis of many human diseases, including chronic kidney disease. The kidney is a very sensitive organ to alterations in sphingolipid metabolism. The critical issues to be addressed in this review relate to the role of sphingolipids and enzymes involved in sphingolipid metabolism in the pathogenesis of glomerular diseases with a special focus on podocytes, a key cellular component of the glomerular filtration barrier. Among several sphingolipids, we will highlight the role of ceramide, sphingosine, sphingosine-1-phosphate and ceramide-1-phosphate. Additionally, we will summarize the current knowledge with regard to the use of sphingolipids as therapeutic agents for the treatment of podocyte injury in kidney disease.