Perirhinal firing patterns are sustained across large spatial segments of the task environment
Perirhinal firing patterns are sustained across large spatial segments of the task environment
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DOI：
10.1038/ncomms15602
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发表时间：
2017-05-26
影响因子：
16.6
通讯作者：
Pennartz, Cyriel M. A.
中科院分区：
文献类型：
--
作者：
Bos, Jeroen J.;Vinck, Martin;Pennartz, Cyriel M. A.
空间导航和记忆取决于生物体位置的神经编码。人们认为位置的细粒度编码取决于海马。同样，动物受益于知识将其环境解析为更大的空间段，这与任务绩效有关。在这里，我们研究了如何编码此类知识，以及这是否发生在颞叶中的结构中，向海马供应皮质输入。我们发现，大鼠周围皮层中的神经元会产生持续的射击模式，以区分任务环境的大部分。这与海马和感觉新皮层中的瞬时发射形成对比。这些空间扩展的模式未通过任务变量或时间离散的感觉刺激来解释。以前已经提出，周围皮层是途径处理对象的一部分，而不是空间信息。我们的结果表明，与该二分法所捕获的神经编码相比，神经编码的复杂性更大。
Spatial navigation and memory depend on the neural coding of an organism's location. Fine-grained coding of location is thought to depend on the hippocampus. Likewise, animals benefit from knowledge parsing their environment into larger spatial segments, which are relevant for task performance. Here we investigate how such knowledge may be coded, and whether this occurs in structures in the temporal lobe, supplying cortical inputs to the hippocampus. We found that neurons in the perirhinal cortex of rats generate sustained firing patterns that discriminate large segments of the task environment. This contrasted to transient firing in hippocampus and sensory neocortex. These spatially extended patterns were not explained by task variables or temporally discrete sensory stimuli. Previously it has been suggested that the perirhinal cortex is part of a pathway processing object, but not spatial information. Our results indicate a greater complexity of neural coding than captured by this dichotomy.