Pharmacological effects of rutaecarpine as a cardiovascular protective agent.
Pharmacological effects of rutaecarpine as a cardiovascular protective agent.
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DOI：
10.3390/molecules15031873
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发表时间：
2010-03-15
期刊：
影响因子：
--
通讯作者：
Hu C
中科院分区：
文献类型：
--
作者：
Jia S;Hu C
许多研究表明，传统中药对心血管疾病的预防和治疗具有重要作用。吴茱萸是我国传统上最常用的治疗头痛、腹痛、产后出血、痢疾和闭经的多用途中药。吴茱萸次碱是从'吴楚玉'中分离得到的吲哚并吡啶喹唑啉类生物碱之一。吴茱萸次碱具有心血管生物学作用，如变力性和变时性、血管舒张、抗血小板聚集和抗炎作用。此外，据报道，吴茱萸次碱对一些心血管疾病具有有益作用。本文综述了近年来有关吴茱萸次碱心血管药理作用的文献，旨在为吴茱萸次碱治疗心血管疾病提供更多的证据。
Many studies indicate that traditional Chinese herbs are beneficial in the prevention and treatment of cardiovascular diseases. Evodia rutaecarpa (‘Wu-Chu-Yu’) remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from ‘Wu-Chu-Yu’. Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. This review summarizes data on the cardiovascular pharmacological actions of rutaecarpine the published over the recent years, aiming to provide more evidence supporting its use in the treatment of cardiovascular diseases.
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