XPC: Going where no DNA damage sensor has gone before.
XPC: Going where no DNA damage sensor has gone before.
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DOI：
10.1016/j.dnarep.2015.09.004
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发表时间：
2015-12
期刊：
影响因子：
3.8
通讯作者：
Gong F
中科院分区：
文献类型：
--
作者：
Nemzow L;Lubin A;Zhang L;Gong F
XPC长期以来被认为是全球基因组核苷酸切除修复（GG-NER）过程中DNA损伤识别的工具。虽然这种识别对于生物体的健康和生存至关重要，但由于XPC对病变的识别刺激了全局基因组修复，最近的研究发现了许多XPC发挥作用的新的非经典途径，如碱基切除修复（BER），染色质重塑，细胞信号传导，蛋白水解降解和细胞活力。自从第一次发现其酵母同系物Rad 4以来，XPC在细胞调节中的参与已经大大扩展。事实上，我们的理解似乎只是触及XPC对维持正常细胞功能的令人难以置信的潜在影响的表面。在这里，我们首先回顾了XPC在病变识别中的典型作用，然后探索XPC功能的新世界。
XPC has long been considered instrumental in DNA damage recognition during global genome nucleotide excision repair (GG-NER). While this recognition is crucial for organismal health and survival, as XPC's recognition of lesions stimulates global genomic repair, more recent lines of research have uncovered many new non-canonical pathways in which XPC plays a role, such as base excision repair (BER), chromatin remodeling, cell signaling, proteolytic degradation, and cellular viability. Since the first discovery of its yeast homolog, Rad4, the involvement of XPC in cellular regulation has expanded considerably. Indeed, our understanding appears to barely scratch the surface of the incredible potential influence of XPC on maintaining proper cellular function. Here, we first review the canonical role of XPC in lesion recognition and then explore the new world of XPC function.