Hippocampal lesions do not impair negative patterning: a challenge to configural association theory.
Hippocampal lesions do not impair negative patterning: a challenge to configural association theory.
复制标题
海马病变不会损害负性模式：对构型关联理论的挑战。
DOI：
10.1037//0735-7044.107.2.227
复制
发表时间：
1993
影响因子：
1.9
通讯作者：
Jarrard,LE
中科院分区：
文献类型：
--
作者：
Davidson,TL;McKernan,MG;Jarrard,LE
根据脑联想（CAS）理论（Sutherland & Rudy，1989），大鼠需要完整的海马来解决基于“脑”过程的学习问题。该理论将消极模式化歧视确定为这类问题的一个重要例子。Rudy和Sutherland（1989）报道了通过颅内输注红藻氨酸+秋水仙碱（KA+ COL）的混合物引起的海马结构损伤后的负性模式破坏。我们评估了收购的负图案与KA+ COL海马损伤的大鼠相比，更有选择性的鹅膏状海马病变的大鼠。相对于对照组，两组均未显示受损的负性模式。转移测试提供的证据表明，所有组使用的图形过程来解决问题。因此，与CAS理论相反，海马不是神经过程运作的重要基质。
According to configural association (CAS) theory (Sutherland & Rudy, 1989), an intact hippocampus is required for rats to solve learning problems that are based on “configural” processes. This theory identifies the negative patterning discrimination as a critical example of this type of problem. Rudy and Sutherland (1989) reported disruption of negative patterning following hippocampal formation damage produced by intracranial infusion of a mixture of kainic acid+ colchicine (KA+ COL). We assessed acquisition of negative patterning in rats with hippocampal damage produced by KA+ COL compared with rats with more selective ibotenate lesions of hippocampus. Neither group showed impaired negative patterning relative to controls. A transfer test provided evidence that all groups used configural processes to solve the problem. Thus contrary to CAS theory, the hippocampus is not an important substrate for the operation of configural processes.