MOUSE COL18A1 IS EXPRESSED IN A TISSUE-SPECIFIC MANNER AS 3 ALTERNATIVE VARIANTS AND IS LOCALIZED IN BASEMENT-MEMBRANE ZONES
MOUSE COL18A1 IS EXPRESSED IN A TISSUE-SPECIFIC MANNER AS 3 ALTERNATIVE VARIANTS AND IS LOCALIZED IN BASEMENT-MEMBRANE ZONES
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DOI：
10.1073/pnas.92.19.8763
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发表时间：
1995-09-12
影响因子：
11.1
通讯作者：
OLSEN, BR
中科院分区：
文献类型：
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作者：
MURAGAKI, Y;TIMMONS, S;OLSEN, BR
我们已经分离出编码小鼠α 1（XVIII）胶原蛋白的N-末端非三螺旋区的重叠cDNA，并表明存在α 1（XVIII）胶原蛋白的三种不同变体。三种变体中的每一种都显示出特征性的组织特异性表达模式。免疫组织化学研究显示，肠绒毛、脉络丛、皮肤、肝脏和肾脏中血管基底膜区的α 1（XVIII）胶原沿着呈阳性染色。因此，我们得出结论，α 1（XVIII）胶原蛋白可能相互作用（直接或间接）与基底膜区或基底表面的内皮/上皮细胞的组件。
We have isolated overlapping cDNAs encoding the N-terminal non-triple-helical region of mouse alpha 1(XVIII) collagen and shown that three different variants of alpha 1(XVIII) collagen exist. Each of the three variants shows characteristic tissue-specific expression, patterns. Immunohistochemical studies show positive staining for alpha 1(XVIII) collagen along the basement membrane zones of vessels in the intestinal villi, the choroid plexus, skin, liver, and kidney. Thus, we conclude that alpha 1(XVIII) collagen may interact (directly or indirectly) with components in basement membrane zones or on the basal surface of endothelial/epithelial cells.